{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:22:05Z","timestamp":1759702925320},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9841,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The initial clinical and laboratory data of 25 patients with acquired idiopathic sideroblastic anemia (AISA) were anlayzed. Criteria for accepting the diagnosis were hyperferremia, ringed marrow sideroblasts, ineffective erythropoiesis, and exclusion of associated hematologic disorders. The findings of a mean age at onset of 70 years, increased mean corpuscular volume, relative neutropenia, and occasional splenomegaly at diagnosis corresponded with previous reports.<\/jats:p><jats:p>During the followup for a median period of 32 months, 6 patients (25%) transformed to acute myelogenous or myelomonocytic leukemia after widely variable intervals. The initial data base of these patients was compared to that of the remaining 19 patients in order to isolate predictive features. Only a lesser degree of hyperferremia (P &lt; 0.001) made the group going on to leukemia distinctive. The median survival of these patients was 20 months. The median survival of 19 patients not developing leukemia was 72 months for males and 42 months for females\n.<\/jats:p><jats:p>Hemochromatosis was diagnosed in four patients and was a primary or associated cause of death in three. Analysis of the transfusion history suggested that intrinsic iron leading was a major factor in these patients.<\/jats:p><jats:p>We conclude that leukemic transformation in AISA is a common, poorly predictable event which required lengthy followup for detection. Hemochromatosis in AISA occurs frequently and shortens the median survival.<\/jats:p>","DOI":"10.1002\/ajh.2830060404","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:22:47Z","timestamp":1172035367000},"page":"323-331","source":"Crossref","is-referenced-by-count":16,"title":["Leukemia in patients with acquired idiopathic sideroblastic anemia: An evaluation of prognostic indicators"],"prefix":"10.1002","volume":"6","author":[{"given":"Robert Ira","family":"Lewy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Kansu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gabuzda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1965.tb00085.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197105000-00001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V15.1.1.1","article-title":"Refractory anemia with hyperplastic marrow","volume":"15","author":"Vilter RW","year":"1960","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1182\/blood.V11.3.250.250","article-title":"Chronic refractory anemia with sideroblastic bone marrow. A study of four cases","volume":"11","author":"Bjorkman S","year":"1956","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-61-6-1029"},{"key":"e_1_2_1_7_2","volume-title":"Statistical Methods","author":"Snedecor W","year":"1967"},{"key":"e_1_2_1_8_2","first-page":"270","article-title":"Calculation of survival rates for cancer. Proc Staff Mtgs","volume":"5","author":"Berkson J","year":"1950","journal-title":"May Clinic"},{"key":"e_1_2_1_9_2","series-title":"DHEW publication # (HRA) 75\u20101150","volume-title":"United States Life Tables (1969\u20101971)","year":"1975"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1182\/blood.V50.3.427.427","article-title":"Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia","volume":"50","author":"Streeter RR","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1182\/blood.V51.4.766.766","article-title":"Prognostic value of platelet counts in idiopathic sideroblastic anemia (letter)","volume":"51","author":"Lewy RI","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/274590a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90238-0"},{"key":"e_1_2_1_14_2","first-page":"479","article-title":"Editorial. Desferrioxamine and transfusional iron overload","volume":"1","year":"1978","journal-title":"Lancet"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90551-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196607282750401"},{"key":"e_1_2_1_17_2","first-page":"133","article-title":"Effect of pyridoxine plus chronic phlebotomy on the function and morphology of bone marrow and liver in pyridoxine responsive sideroblastic anema","volume":"13","author":"Hines JD","year":"1976","journal-title":"Seminar Hematol"},{"key":"e_1_2_1_18_2","first-page":"594","article-title":"Sideroblastic anemia associated with iron overload treated by repeat phlebotomy","volume":"50","author":"French TJ","year":"1976","journal-title":"S African Med J"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830060404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830060404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:27:33Z","timestamp":1699842453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830060404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,8]]}},"alternative-id":["10.1002\/ajh.2830060404"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830060404","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,8]]}}}