{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:07Z","timestamp":1761058627190},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9657,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A young American woman of Thai ancestry living in Ohio and a man of Vietnamese origin living in Iowa are believed to be the first recognized hemoglobin E homozygotes residing in the western hemisphere. Both were clinically well and exhibited neither pallor nor icterus nor splenomegaly. Their blood exhibited marked microcytosis and mild erythrocytosis. Hemoglobin was 99% E and 1% F, 97% E and 3% F, respectively. These features were similar to those previously reported from Southeast Asia and Madagascar in the few well\u2010documented reports of homozygous hemoglobin E. A <jats:sup>51<\/jats:sup>Cr erythrocyte survival study indicated a normal t<jats:sub>1\/2<\/jats:sub> of 28 days. Also demonstrated were minimal decrease in whole blood O<jats:sub>2<\/jats:sub> affinity and increased ratio of \u03b1\/non\u2010\u03b1 globin chain synthesis. Mild hemolytic anemia is not, as usually stated, a feature of this condition, which closely mimics a very mild thalassemia minor. Anemia, when found with high proportions of hemoglobin E, should not be attributed to the homozygous hemoglobinopathy. Persons with homozygous hemoglobin E should be reassured as to its benign implications.<\/jats:p>","DOI":"10.1002\/ajh.2830080112","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:48:11Z","timestamp":1172036891000},"page":"109-121","source":"Crossref","is-referenced-by-count":42,"title":["Homozygous hemoglobin E mimics \u03b2\u2010thalassemia minor without anemia or hemolysis: Hematologic, functional, and biosynthetic studies of first north American cases"],"prefix":"10.1002","volume":"8","author":[{"given":"Virgil F.","family":"Fairbanks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhaiza","family":"Oliveros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Brandabur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Fiester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"553","article-title":"Hemoglobin E\u2010thalassemia disease","volume":"11","author":"Chatterjea JB","year":"1957","journal-title":"Indian J Med Sci"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood.V42.5.783.783","article-title":"The interaction of hemoglobin E with \u03b2 thalassemia: A study of hemoglobin synthesis in a family of mixed Burmese and Iranian origin","volume":"42","author":"Feldman R","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_4_2","first-page":"377","article-title":"Some aspects of haemoglobin E and its genetic interaction with thalassaemia","volume":"53","author":"Chatterjea JB","year":"1965","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_5_2","first-page":"455","article-title":"Studies on hemoglobin E. 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