{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:37:17Z","timestamp":1699922237832},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9536,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1980,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A boy with recurrent pyogenic infection was found to have occasional neutropenia, defective neutrophil chemotaxis, hypogammaglobulinemia with increased IgM, and impaired cellular immunity. The T and B lymphocytes were defective in IgG production in vitro. Ultrastructure of the neutrophils was normal. The marrow cells formed normal numbers of granulocytic colonies in culture, but the colonies were apparently small in size. The levels of colony\u2010stimulating activity were normal. The lymphocytes did not impair granulopoiesis of control marrow cells. These data indicate that the neutropenia and defective neutrophil chemotaxis are due to the intrinsic neutrophil defects and are not secondary to T and\/or B lymphocyte dysfunctions in the patient.<\/jats:p>","DOI":"10.1002\/ajh.2830080409","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:31:50Z","timestamp":1172035910000},"page":"403-409","source":"Crossref","is-referenced-by-count":3,"title":["Intrinsic neutrophil defects in a child with impaired neutrophil chemotaxis and immunodeficiency"],"prefix":"10.1002","volume":"8","author":[{"given":"Hironori","family":"Morosawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munehiro","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroharu","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Akabane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-4-515"},{"key":"e_1_2_1_3_2","first-page":"618","article-title":"Raised serum\u2010IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections","volume":"1","author":"Hill HR","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.1.63"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80068-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1542\/peds.65.3.497","article-title":"Delayed in vitro immunoglobulin production by cord lymphocytes","volume":"65","author":"Miyagawa Y","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90196-7"},{"key":"e_1_2_1_8_2","first-page":"25","volume-title":"Leukocyte Chemotaxis: Methods, Physiology, and Clinical Implications","author":"Nelson RD","year":"1978"},{"key":"e_1_2_1_9_2","first-page":"511","article-title":"A simple rapid micromethod for detecting chronic granulomatous disease of childhood","volume":"75","author":"Gifford RH","year":"1970","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1955.tb45983.x"},{"key":"e_1_2_1_11_2","first-page":"316","article-title":"A modified assay of neutrophil function. Use of lysostaphin to differentiate defective phagocytosis from impaired intracellular killing","volume":"78","author":"Tan JS","year":"1971","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80343-1"},{"key":"e_1_2_1_13_2","first-page":"249","volume-title":"Hemopoietic Cellular Proliferation","author":"Robinson WA","year":"1970"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197402282900903"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80004-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1542\/peds.59.5.739","article-title":"Evaluation of congenital neutropenic disorders by in vitro bone marrow culture","volume":"59","author":"Falk PM","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90060-8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1542\/peds.59.3.396","article-title":"Abnormal in vitro granulopoiesis in phenotypically normal parents of some children with congenital neutropenia","volume":"59","author":"Rich K","year":"1977","journal-title":"Pediatrics"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830080409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830080409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:37:44Z","timestamp":1699850264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830080409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,6]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,6]]}},"alternative-id":["10.1002\/ajh.2830080409"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830080409","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,6]]}}}