{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:40:34Z","timestamp":1699832434467},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9475,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1980,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several (14) commercially prepared, lyophilized Factor VIII concentrates were assayed for VIII<jats:sub>AHF<\/jats:sub>, VIII<jats:sub>Ag<\/jats:sub>, and VIII<jats:sub>VWF<\/jats:sub>. Significant levels of VIII<jats:sub>Ag<\/jats:sub> (immunologic) and VIII<jats:sub>VWF<\/jats:sub> (von Willebrand Factor) were present in addition to VIII<jats:sub>AHF<\/jats:sub> (Functional VIII, Antihemophilic Factor, Factor VIII coagulant activity). An average of 0.95 units of VIII<jats:sub>VWF<\/jats:sub> (range 0.47\u20131.7) were present for every 1.0 unit of VIII<jats:sub>AHF<\/jats:sub> (as stated on the manufacturer's label). We suggest that the various lyophilized preparations of Factor VIII concentrate available could be assayed for VIII<jats:sub>VWF<\/jats:sub> and should be tested therapeutically in patients with von Willebrand disease.<\/jats:p>","DOI":"10.1002\/ajh.2830090105","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:27:11Z","timestamp":1172035631000},"page":"39-42","source":"Crossref","is-referenced-by-count":2,"title":["Von willebrand factor (VIII<sub>VWF<\/sub>) in lyophilized factor VIII concentrates"],"prefix":"10.1002","volume":"9","author":[{"given":"Miles J.","family":"McCue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur D.","family":"Brossoit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Marmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"231","article-title":"Von Willebrand's disease","volume":"3","author":"Hoyer LW","year":"1976","journal-title":"Prog Hemostasis Thromb"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90826-9"},{"key":"e_1_2_1_4_2","unstructured":"JessicaLewis MD: Personal communication. Central Blood Bank of Pittsburgh Pittsburgh Pennsylvania."},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1182\/blood.V30.3.375.375","article-title":"Correction of the hemostatic defects in von Willebrand's disease","volume":"30","author":"Perkins HA","year":"1967","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb00817.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90751-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90834-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb01028.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.236.24.2770"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/ajcp\/72.6.991","article-title":"An improved assay for von Willebrand's factor","volume":"72","author":"Head DR","year":"1979","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_12_2","first-page":"14","volume-title":"Hemostasis Seminar","author":"Lenahan J","year":"1974"},{"key":"e_1_2_1_13_2","first-page":"152","article-title":"Determination of the von Willebrand's disease antigen (Factor VIII\u2010related antigen) in plasma by quantitative immunoelectrophoresis","volume":"86","author":"Zimmerman TS","year":"1975","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1978.tb02898.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830090105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830090105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:07:45Z","timestamp":1699830465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830090105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,8]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,8]]}},"alternative-id":["10.1002\/ajh.2830090105"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830090105","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,8]]}}}