{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:40:21Z","timestamp":1699832421256},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9475,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1980,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hand mirror cell (HMC) in infectious mononucleosis (IM) is a T cell which appears at the time of improvement and apparently has an important role in immune surveillance. Fifty electron micrographs of HMC from an unusual untreated patient with ALL\u2010HMC variant were compared to 50 electron micrographs of HMC from five patients beginning to recover from IM. Quantitative differences between the IM\u2010HMC and ALL\u2010HMC were observed in multivariate analysis of variance (p &lt; 0.001), nuclear perimeter (p &lt; 0.0001), nuclear length (p &lt; 0.0001), cytoplasmic length (p &lt; 0.0001), total cell area (p &lt; 0.0001), cytoplasmic area (p &lt; 0.0001) and nuclear cytoplasmic ratio (p &lt; 0.004), and numbers of mitochondria (p &lt; 0.001). The qualitative differences included greater nuclear irregularity in the IM\u2010HMC, and prominent nucleolonema in some of the ALL\u2010HMC. In addition, the IM\u2010HMC showed more polyribosomes, parallel tubular arrays and microtubules, but much less glycogen. Since the IM\u2010HMC apparently enter effectively into immune surveillance, and some cases of ALL have HMC, the ultrastructural similarities and differences above contribute to a better understanding of the importance of this unique cell configuration in benign and malignant disorders.<\/jats:p>","DOI":"10.1002\/ajh.2830090108","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:27:11Z","timestamp":1172035631000},"page":"67-77","source":"Crossref","is-referenced-by-count":7,"title":["Infectious mononucleosis and acute lymphoblastic leukemia\u2014hand mirror cells: A qualitative and quantitative ultrastructural study"],"prefix":"10.1002","volume":"9","author":[{"given":"H. R.","family":"Schumacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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L.","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92260-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92096-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92764-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80583-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830040109"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.5.1037"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.4049\/jimmunol.114.2_Part_2.802","article-title":"The modulation of spontaneous and anti\u2010Ig\u2010stimulated motility of lymphocytes by cyclic nucleotides and adrenergenic and cholenergic agents","volume":"114","author":"Schreiner GF","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1974.tb00273.x"},{"issue":"2","key":"e_1_2_1_10_2","first-page":"69","article-title":"Amoeboid movement configuration and mitotic indices of lymphoid cells from children with acute lymphoblastic leukemia","volume":"9","author":"Sjogren U","year":"1976","journal-title":"Lymphology"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1977.tb15716.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830070103"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ajcp\/72.4.551","article-title":"Acute lymphoblastic leukemia \u2010 mirror variant. 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