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In each patient studied, chromosomal modes were in the hypodiploid or near\u2010diploid range. Despite the karyotypic abnormalities, the cellular DNA content, as determined by flow microfluorometry, was within normal limits in all cases. This suggests that the variability in chromosome numbers seen in these patients may reflect an abnormality in DNA packaging rather than differences in total DNA content. The modal electronic cell size of the prolymphocytes, determined by light scatter, was readily distinguishable from that of normal peripheral blood lymphocytes and the lymphocytes of chronic lymphocytic leukemia. Fewer than 4% of the peripheral prolymphocytes had S\u2010phase DNA content, a finding consistent with the chronic nature of this leukemia.<\/jats:p>","DOI":"10.1002\/ajh.2830090311","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:45:33Z","timestamp":1172040333000},"page":"319-330","source":"Crossref","is-referenced-by-count":14,"title":["Prolymphocytic leukemia: Flow microfluorometric, immunologic, and cytogenetic observations"],"prefix":"10.1002","volume":"9","author":[{"given":"Lawrence W.","family":"Diamond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Bearman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula K.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie J.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat N.","family":"Nathwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis D.","family":"Weisenburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl D.","family":"Winberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond L.","family":"Teplitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Rappaport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06769.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0308-2261(21)00561-0","article-title":"Hairy\u2010cell leukaemia and prolymphocytic leukaemia","volume":"6","author":"Catovsky D","year":"1977","journal-title":"Clin Haematol"},{"key":"e_1_2_1_4_2","first-page":"237","article-title":"Prolymphocytic leukaemia: Cell studies and treatment by leucopheresis","volume":"18","author":"Buskard NA","year":"1976","journal-title":"Haematol Bluttransfus"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93135-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1105517"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66639-1_20"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197811)42:5<2360::AID-CNCR2820420537>3.0.CO;2-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/73.2.150"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92127-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1103834"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb05835.x"},{"key":"e_1_2_1_13_2","first-page":"811","volume-title":"Differentiation of Normal and Neoplastic Hematopoietic Cells","author":"Catovsky D","year":"1978"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00996689"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197908)44:2<580::AID-CNCR2820440226>3.0.CO;2-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.1.98"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb07111.x"},{"key":"e_1_2_1_18_2","first-page":"61","article-title":"Membrane phenotyping: Diagnosis, monitoring and classification of acute \u201clymphoid\u201d leukaemias","volume":"20","author":"Greaves MF","year":"1977","journal-title":"Haematol Bluttransfus"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.212.9.1488"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio232031a0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/226078a0"},{"key":"e_1_2_1_22_2","first-page":"703","article-title":"Flow analysis of DNA content and cell size in non\u2010Hodgkin's lymphoma","volume":"40","author":"Diamond LW","year":"1980","journal-title":"Cancer Res"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02339807"},{"key":"e_1_2_1_24_2","unstructured":"DiamondLW BraylanRC BearmanRM WinbergCD RappaportH: The determination of cellular DNA content in neoplastic and nonneoplastic lymphoid populations by flow microfluorometry. 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