{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:35:18Z","timestamp":1756308918974},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":12042,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1980,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The function of the pituitary\u2010adrenal axis and leukocyte alkaline phosphatase activity were evaluated in eight patients with sickle cell disease during a painful crisis and when crisis\u2010free. The leukocyte alkaline phosphatase (LAP) score did not increase during crisis; the scores were in the low\u2010normal range during crisis and noncrisis periods. Insulin\u2010induced hypoglycemia produced normal growth hormone responses during both crisis and crisis\u2010free periods. Plasma cortisol concentrations were diminished in the crisis group. Also impaired was 11\u2010deoxycortisol production in both groups after metyrapone. These findings indicate that a mild defect in the hypothalamic\u2010pituitary\u2010adrenal axis exists in sickle cell disease patients.<\/jats:p>","DOI":"10.1002\/ajh.2830090404","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T14:34:30Z","timestamp":1384958070000},"page":"373-379","source":"Crossref","is-referenced-by-count":7,"title":["Pituitary\u2010adrenal axis function in sickle cell anemia and its relationship to leukocyte alkaline phosphatase"],"prefix":"10.1002","volume":"9","author":[{"given":"Barry E.","family":"Rosenbloom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Odell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi R.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-5-668"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197510302931810"},{"key":"e_1_2_1_4_2","first-page":"219","article-title":"Studies on leukocyte alkaline phosphatase activity: Relation to \u201cstress\u201d and pituitary\u2010adrenal activity","volume":"44","author":"Valentine WN","year":"1954","journal-title":"J Lab Din Med"},{"key":"e_1_2_1_5_2","first-page":"723","article-title":"The relationship of leukocyte alkaline phosphatase to \u201cstress\u201d, to ACTH, and to adrenal 17\u2013OH\u2010corticosteroids","volume":"49","author":"Valentine WN","year":"1957","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03230340022022"},{"key":"e_1_2_1_7_2","volume-title":"\u201cTextbook of Endocrinology.\u201d","author":"Ensinck JW","year":"1974"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/archinte.1970.00310030082008","article-title":"Single\u2010dose metyrapone test","volume":"125","author":"Jubiz W","year":"1970","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/39.5.439"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/200690a0"},{"key":"e_1_2_1_11_2","first-page":"39","article-title":"Biochemical studies on leucocytes. 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Phosphatase activity in health, leucocytosis and myelocytic leukemia","volume":"38","author":"Valentine WN","year":"1951","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","first-page":"980","article-title":"Low leukocyte alkaline phosphatase activity in sickle cell anemia","volume":"72","author":"Wajima T","year":"1968","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_13_2","first-page":"303","article-title":"Studies on leukocyte alkaline phosphatase: Role of zinc and magnesium","volume":"55","author":"Valentine WN","year":"1960","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/clinchem\/21.4.582","article-title":"Zinc deficiency in sickle cell disease","volume":"21","author":"Prasad AS","year":"1975","journal-title":"Clin Chem"},{"key":"e_1_2_1_15_2","first-page":"144","article-title":"Biochemical effects of zinc deficiency: Changes in activities of zinc\u2010dependent enzymes and ribonucleic acid and deoxyribonucleic acid content of tissues","volume":"77","author":"Prasad AS","year":"1971","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-5-601"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)91526-6"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830090404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830090404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:18:02Z","timestamp":1699849082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830090404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,12]]}},"alternative-id":["10.1002\/ajh.2830090404"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830090404","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,12]]}}}