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Anti\u2010T\u2010cell antiserum proved useful in characterizing the phenotype of the abnormal cells when only a minority of the abnormal cells formed E\u2010rosettes. Anti\u2010B\u2010cell antiserum was consistently unreactive with the abnormal cells. Terminal transferase was elevated in T\u2010cell ALL but low in T\u2010cell CLL, lymphoma\u2010leukemia, or S\u00e9zary syndrome. Lymphocyte proliferative response to nonspecific mitogens was generally depressed as was the response to allogeneic cells. The cells also failed to stimulate in mixed lymphocyte culture, implying a lack of Ia antigens on their surface. Acid phosphatase stain was positive in the three patients tested. Peroxidase and esterase stains were negative, whereas PAS was positive in five of eight patients tested. Prognosis in general, regardless of the clinical picture, (ie, acute, chronic, or lymphoma\u2010leukemia), was poor with seven of the nine patients dying within 14 months of diagnosis. Therefore, the use of anti\u2010T\u2010cell antisera and the E\u2010rosette surface marker should be used to characterize the phenotype of the malignant cells in lymphoproliferative disease to enable more vigorous treatment of those that are of T\u2010cell origin and that therefore carry a poor prognosis.<\/jats:p>","DOI":"10.1002\/ajh.2830100105","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:45:22Z","timestamp":1172040322000},"page":"19-30","source":"Crossref","is-referenced-by-count":1,"title":["The immunological and cytochemical characterization of T\u2010cell lymphoproliferative diseases"],"prefix":"10.1002","volume":"10","author":[{"given":"T. J.","family":"Spira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. W.","family":"Ades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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