{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:36:24Z","timestamp":1773657384735,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9291,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This report describes three patients with factor (F) VII deficiency: two adult siblings and an unrelated 5\u00bd\u2010month\u2010old child who succumbed after several central nervous system (CNS) hemorrhages. This event prompted a review of the literature concerning the incidence and characteristics of intracranial hemorrhage in congenital F VII deficiency.<\/jats:p><jats:p>Of 138 patients reported to have F VII deficiency, only 75 were considered to have a true deficiency. There was a 1:1 sex distribution with a 19% incidence of consanguinity in the 63 families which these 75 patients represented.<\/jats:p><jats:p>CNS hemorrhage occurred in 12 of the 75 proven factor\u2010deficient patients \u2013 an incidence of 16.0%. There was a 1.4:1 female predominance in this group, with a 44.4% incidence of consanguinity in their nine families. Except for one patient with hypertension, there was no history of preceding trauma or previous underlying CNS abnormality, though head trauma with a difficult vaginal delivery may have occurred in five infants. Diagnostic lumbar puncture or ventricular tap revealed bloody, xanthochromic cerebrospinal fluid in five.<\/jats:p><jats:p>Five patients with F VII deficiency developed a CNS hemorrhage prior to 1 week of age, and none survived. Seven patients older than 1 week of age suffered such an event, and four of these survived. It is concluded that the greatest risk factor for development of CNS hemorrhage is trauma related to the birth process.<\/jats:p>","DOI":"10.1002\/ajh.2830100112","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:45:22Z","timestamp":1172040322000},"page":"79-88","source":"Crossref","is-referenced-by-count":120,"title":["Factor VII deficiency"],"prefix":"10.1002","volume":"10","author":[{"given":"Margaret V.","family":"Ragni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica H.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel A.","family":"Spero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Hasiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"98","article-title":"Sur le pouvoir coagulant du serum","volume":"18","author":"Bordet J","year":"1904","journal-title":"Ann Inst Pasteur"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1152\/ajplegacy.1955.181.3.589","article-title":"Formation of autoprothrombin in solutions containing purified prothrombin and purified platelet factor 3","volume":"181","author":"Seegers WH","year":"1955","journal-title":"Am J Physiol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ajcp\/20.3.225","article-title":"The complex mechanisms of the Quick prothrombin test and the effect of dicumarol","volume":"20","author":"Mann FD","year":"1950","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1152\/ajplegacy.1950.164.1.105","article-title":"Co\u2010thromboplastin, a probable factor in coagulation of blood","volume":"164","author":"Mann FD","year":"1951","journal-title":"Am J Physiol"},{"key":"e_1_2_1_6_2","first-page":"1","article-title":"The coagulation of blood: Investigations on a new clotting factor","volume":"194","author":"Owren PA","year":"1947","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_7_2","first-page":"1203","article-title":"The state of component A (prothrombin) in human blood: Evidence that it is partly free and partly in inactive or precursor form","volume":"34","author":"Quick AJ","year":"1949","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/ajplegacy.1951.166.1.1","article-title":"Prothrombin conversion factors in blood coagulation","volume":"166","author":"Owen CA","year":"1951","journal-title":"Am J Physiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1182\/blood.V4.6.739.739","article-title":"Factor in serum which accelerates conversion of prothrombin to thrombin (II): Its evolution with special reference to influence of condition which affect blood coagulation","volume":"4","author":"Alexander B","year":"1949","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102322"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(53)90019-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000203899"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102477"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.73040490010008"},{"key":"e_1_2_1_15_2","first-page":"1","article-title":"Hemostasis and hemorrhage","volume":"1","author":"Lewis JH","year":"1971","journal-title":"Sci Clin"},{"key":"e_1_2_1_16_2","first-page":"22","volume-title":"Diagnostic Methods: Laboratory Tests. 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