{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:06:32Z","timestamp":1778857592393,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9291,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two cases of von Willebrand disease (vWD) associated with familial thrombocytopenia were reported. The proband (daughter) and her father showed thrombocytopenia with large platelets and decreased von Willebrand factor activity (VIIIR:WF). Factor VIII procoagulant activity (VIII:C) and factor VIII\u2010related antigen (VIIIR:AG) were normal, but both patients revealed an increased ristocetin\u2010induced platelet aggregation and a qualitative abnormality of the factor VIII protein, which was characterized by fast electrophoretic mobility of VIIIR:AG and an abnormal elution of factor VIII\u2010related activities on Sepharose 2B. DDAVP was hemostatically effective even in this thrombocytopenic patient undergoing a dental extraction.<\/jats:p>","DOI":"10.1002\/ajh.2830100113","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:45:22Z","timestamp":1172040322000},"page":"89-99","source":"Crossref","is-referenced-by-count":22,"title":["von Willebrand disease associated with familial thrombocytopenia and increased ristocetin\u2010induced platelet aggregation"],"prefix":"10.1002","volume":"10","author":[{"given":"Hoyu","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reizo","family":"Nagayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Ihzumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneyasu","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1963.tb05457.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90798-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197303000-00006"},{"key":"e_1_2_1_5_2","first-page":"27","article-title":"Dominant inherited familial factor VIII deficiency (von Willebrand disease) associated with thrombocytopathic thrombocytopaenia","volume":"22","author":"Sultan Y","year":"1974","journal-title":"Pathol Biol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(77)90204-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1910.04330140029009"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-0609.1970.tb01917.x","article-title":"Platelet adhesiveness in von Willebrand's disease: A study with a new modification of the glass bead filter method","volume":"7","author":"Hellem AJ","year":"1970","journal-title":"Scand J Haematol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194709000-00008"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1965.tb06586.x"},{"key":"e_1_2_1_11_2","first-page":"637","article-title":"Effect of antihemophilic factor on one\u2010stage clotting tests","volume":"41","author":"Langdell R","year":"1953","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90246-6"},{"key":"e_1_2_1_13_2","first-page":"318","article-title":"Platelets fixed with paraformaldehyde: A new reagent for assay of von Willebrand factor and platelet aggregating factor","volume":"85","author":"Allain JP","year":"1975","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651343"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007185"},{"key":"e_1_2_1_16_2","first-page":"359","article-title":"Hereditary thrombocytopenia","volume":"1","author":"Murphy S","year":"1972","journal-title":"Clin Haematol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0028-1087131","article-title":"Congenital disorders affecting platelets","volume":"4","author":"Lusher JM","year":"1977","journal-title":"Semin Thromb Hemostas"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5195.356"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.14.5.540"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1182\/blood.V40.2.227.227","article-title":"Familial association of thrombopathia and antihemophilic factor (AHF, factor VIII) deficiency","volume":"40","author":"Crowell EB","year":"1972","journal-title":"Blood"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb00484.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197407182910301"},{"key":"e_1_2_1_23_2","unstructured":"TakahashiH:Studies on the pathophysiology and treatment of von Willebrand's disease. IV. Mechanism of increased ristocetin\u2010induced platelet aggregation in von Willebrand's disease. Thromb Res (in press)."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830080308"},{"key":"e_1_2_1_25_2","first-page":"662","article-title":"Studies on the prolonged bleeding time in von Willebrand's disease","volume":"88","author":"Mannucci PM","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91197-7"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830100113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830100113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:17:26Z","timestamp":1699831046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830100113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,2]]}},"alternative-id":["10.1002\/ajh.2830100113"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830100113","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,2]]}}}