{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:26:18Z","timestamp":1784582778192,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9232,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010one cases of pure, primary erythrocytosis were identified and followed at H\u01d2pital Saint\u2010Louis, Paris, and compared with 350 cases of polycythemia vera (PV) observed during the same period. At the initial evaluation, these cases did not differ from PV cases with respect to age, sex ratio, degree of red cell volume increase, and clinical symptoms. They did differ by the absence of splenomegaly, granulocytosis and thrombocytosis. At a late stage of evolution only a few cases developed classical criteria of PV. From this group of apparently homogeneous cases, two subgroups evolved. Sixty percent of the cases were highly responsive to myelosuppression with <jats:sup>32<\/jats:sup>P. The median duration of the first remission was greater than five years, the mean yearly dose of <jats:sup>32<\/jats:sup>P was very low, and there was a low incidence of complications. The other group (40% of cases) was relatively resistant to myelosuppressive agents. The development of better methods to investigate this disorder might help in discriminating these two groups from both an etiological and pathophysiological viewpoint. The thromboembolic risk of these diseases suggests that myelosuppressive therapy should be utilized in older patients with higher risk of vascular accidents, reserving phlebotomy for younger patients and those who are shown to be resistant to <jats:sup>32<\/jats:sup>P therapy.<\/jats:p>","DOI":"10.1002\/ajh.2830100204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:44:57Z","timestamp":1172040297000},"page":"129-136","source":"Crossref","is-referenced-by-count":37,"title":["Pure erythrocytosis: Reappraisal of a study of 51 cases"],"prefix":"10.1002","volume":"10","author":[{"given":"Y.","family":"Najean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Triebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dresch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"5","article-title":"Diagnosis and classification of the polycythemias","volume":"12","author":"Berlin NI","year":"1976","journal-title":"Semin Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1960.03860180108020"},{"key":"e_1_2_1_4_2","first-page":"397","article-title":"Spurious polycythemia","volume":"12","author":"Weinreb NJ","year":"1975","journal-title":"Semin Hematol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1964.03860120046002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1968.tb06989.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1979.tb00467.x"},{"key":"e_1_2_1_8_2","first-page":"795","article-title":"Standard techniques for the measurement of red cell and plasma volume","volume":"25","author":"International Committee for Standardization in Haematology (ICSH)","year":"1973","journal-title":"Br J Haematol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0308-2261(21)00124-7","article-title":"Blood volume in health and disease","volume":"6","author":"Najean Y","year":"1977","journal-title":"Clin Haematol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1978.tb02506.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197801052980102"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-4-512"},{"key":"e_1_2_1_13_2","first-page":"383","article-title":"Familial polycythemia","volume":"12","author":"Adamson JW","year":"1975","journal-title":"Semin Hematol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1182\/blood.V52.2.350.350","article-title":"32P and development of leukemia in a patient with hemoglobin yakima","volume":"52","author":"Bagby GC","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_15_2","unstructured":"RosaR NajeanY PrehuMO BeuzardY RosaJ:Total deficiency of red cell diphospho\u2010glyceromutase and polycythemia. Proc 20th Meeting Am Soc Hematol 1977."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.134.1.113"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01048.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb00989.x"},{"key":"e_1_2_1_19_2","first-page":"13","article-title":"Cytogenetic studies in polycythemia vera","volume":"13","author":"Wurster\u2010Hill D","year":"1976","journal-title":"Semin Hematol"},{"key":"e_1_2_1_20_2","first-page":"1499","article-title":"Les \u00e9l\u00e9ments du choix th\u00e9rapeutique dans les polyglobulies vraies. I. Evolution \u00e0 long terme de 286 malades trait\u00e9s par 32 P","volume":"2","author":"Rain JD","year":"1973","journal-title":"Nouv Presse Med"},{"key":"e_1_2_1_21_2","first-page":"167","article-title":"The treatment of polycythemia vera","volume":"13","author":"Wasserman LR","year":"1976","journal-title":"Semin Hematol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198006000-00011"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196507000-00003"},{"key":"e_1_2_1_24_2","first-page":"33","article-title":"Acute leukemia in polycythemia vera","volume":"13","author":"Landaw SA","year":"1976","journal-title":"Semin Hematol"},{"key":"e_1_2_1_25_2","first-page":"1563","article-title":"La radioleuc\u00e9mog\u00e9n\u00e8se chez l'homme","volume":"108","author":"Tubiana M","year":"1978","journal-title":"Schweiz Med Wochenschr"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830100204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830100204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:13:58Z","timestamp":1699834438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830100204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1002\/ajh.2830100204"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830100204","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}