{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:30:38Z","timestamp":1759336238632},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9232,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some patients with chronic lymphocytic leukemia (CLL) have a relatively stable clinical course without treatment, but many of these eventually develop progressive disease. We have followed 68 patients over 5\u00bd years by employing conventional surface markers and lymphocyte reactivity, including that of separate enriched T cells to their own leukemic B cells, to phytohemagglutinin (PHA), and to normal allogeneic B cells; we have observed an unusual response in each of the seven patients who developed progressive disease over this period of time. During the stable phase of the disease the T cells from 27 leukemic subjects did not respond to their own leukemic B cells in culture. In the seven patients who developed progressive disease, a significant reactivity of their enriched T cells to their own leukemic B cells occurred. There was no consistent change in T\u2010cell reactivity to PHA or to allogeneic B cells, suggesting a change in the leukemic B\u2010cell populations that was not detected morphologically. The change in reactivity of T cells to leukemic B cells occurred prior to evidence of clinical or laboratory deterioration in one of the seven cases; there was increasing lymphocytosis and lymphadenopathy in six and two instances, respectively; and anemia and thrombocytopenia in the three and one cases, respectively.<\/jats:p>","DOI":"10.1002\/ajh.2830100205","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:44:57Z","timestamp":1172040297000},"page":"137-143","source":"Crossref","is-referenced-by-count":1,"title":["Increased T\u2010cell reactivity to leukemic B cells in chronic lymphocytic leukemia with change of stable disease to its progressive form"],"prefix":"10.1002","volume":"10","author":[{"given":"Louis A.","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Michael","family":"MacSween","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Ross","family":"Langley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1005","volume-title":"Hematology","author":"Rundles RW","year":"1977"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V46.2.219.219"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90105-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-1-10"},{"key":"e_1_2_1_6_2","first-page":"670A","article-title":"B and T lymphocyte markers and responsiveness during the evolution of chronic lymphocytic leukemia (CLL), abstracted","volume":"24","author":"Fernandez LA","year":"1976","journal-title":"Clin Res"},{"key":"e_1_2_1_7_2","first-page":"231","article-title":"Separation of T lymphocytes from normal individuals and patients with B lymphocyte chronic lymphocytic 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