{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:02:18Z","timestamp":1777348938143,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9232,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The formation of a uropod by lymphocytes (hand\u2010mirror cells) represents a morphologic stage of immune activation and motility in lymphocytes. Immune complexes have been previously shown to induce hand\u2010mirror\u2010cell (HMC) formation in human lymphocytes and have been associated with increased number of HMC in acute leukemia. We studied the ability of immune complexes to induce HMC in patients with Wiskott\u2010Aldrich syndrome (WAS), a disease of cellular immune deficiency. Our findings indicate that lymphocytes from patients with WAS adhere to immune complexes but have a defect in their ability to form HMC when compared with normal human lymphocytes. These results support the concept that immune complexes induce HMC formation and that the HMC is related to the normal cellular immune response.<\/jats:p>","DOI":"10.1002\/ajh.2830100207","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:44:57Z","timestamp":1172040297000},"page":"157-163","source":"Crossref","is-referenced-by-count":6,"title":["A defect in the formation of uropod\u2010bearing lymphocytes (hand\u2010mirror cells) in patients with the wiskott\u2010aldrich syndrome"],"prefix":"10.1002","volume":"10","author":[{"given":"Thomas P.","family":"McGraw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Folds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K.","family":"Whisnant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry M.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford A.","family":"Stass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"29","article-title":"Locomotion of lymphocytes","volume":"49","author":"Lewis WH","year":"1931","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.5.1260"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(71)90698-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","unstructured":"McFarlandW HeilmanH MoorheadJF:Functional anatomy of the lymphocyte in immunological reactions in vitro. 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