{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:47:00Z","timestamp":1772815620645,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma \u03b2\u2010thromboglobulin (\u03b2\u2010TG), a platelet\u2010specific protein, is a marker of intravascular platelet degranulation. We measured plasma \u03b2\u2010thromboglobulin by radioimmunoassay in 13 patients with thrombocytopenia of various etiologies to determine whether or not the test is clinically useful in the differential diagnosis of thrombocytopenia. Four patients with intravascular platelet consumption (three with thrombotic thrombocytopenic purpura and one with vasculitis) had significantly higher plasma \u03b2\u2010thromboglobulin levels than four patients with extravascular platelet destruction due to idiopathic thrombocytopenic purpura. Five patients with thrombocytopenia and decreased numbers of megakaryocytes in the bone marrow also had \u03b2\u2010thromboglobulin levels that were not elevated. Two patients with thrombotic thrombocytopenic purpura achieved clinical remission associated with a decrease in \u03b2\u2010TG level to the normal range. Plasma \u03b2\u2010thromboglobulin determination can be useful in determining the mechanism of thrombocytopenia when bone marrow examination demonstrates adequate megakaryocyte numbers.<\/jats:p>","DOI":"10.1002\/ajh.2830100406","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:39:34Z","timestamp":1172039974000},"page":"369-373","source":"Crossref","is-referenced-by-count":6,"title":["Clinical use of \u03b2\u2010thromboglobulin levels in diagnosing and treating consumptive and immune thrombocytopenia"],"prefix":"10.1002","volume":"10","author":[{"given":"Martin D.","family":"Rubenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb05855.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V53.4.604.604"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V54.5.1192.1192","article-title":"Plasma beta\u2010thromboglobulin: Differentiation between intravascular and extravascular platelet destruction","volume":"54","author":"Han P","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(80)90294-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197211162872001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb03727.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1182\/blood.V55.1.82.82","article-title":"Plasma concentrations of platelet\u2010specific proteins correlated with platelet survival","volume":"55","author":"Doyle DJ","year":"1980","journal-title":"Blood"},{"issue":"1","key":"e_1_2_1_9_2","first-page":"240a","article-title":"Effects of plasma from patients with thrombotic thrombocytopenic purpura (TTP) on cultured human endothelial cells","volume":"54","author":"Foster P","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_10_2","first-page":"350","article-title":"Immune mediated endothelial cell injury in the pathogenesis of thrombotic thrombocytopenic purpura","volume":"25","author":"Wall R","year":"1977","journal-title":"Clin Res"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-149"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830100406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830100406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:18:20Z","timestamp":1699831100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830100406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,6]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,6]]}},"alternative-id":["10.1002\/ajh.2830100406"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830100406","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,6]]}}}