{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:28:50Z","timestamp":1699835330101},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":9079,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to obtain further knowledge of chronic neutropenia of childhood, we studied nine neutropenic infants six to ten months of age by in vitro techniques, including bone marrow culture, electron microscopy, and chemotaxis assay. Eight of the nine patients had a benign clinical course and the bone marrow aspirates showed a reduced number of segmented neutrophils. The ninth patient had a moderately severe course and the bone marrow showed maturation arrest at the promyelocyte stage. Bone marrow cultures demonstrated that the in vitro neutrophil colony formation and production of colony\u2010stimulating activity were normal in all of the eight patients studied. Neutrophils from one of the nine patients had ultrastructural abnormalities such as a decrease in number of primary and secondary granules and the presence of myelin figures in primary granules. Neutrophil chemotaxis was defective in three of the nine patients. All of the six patients in whom the neutrophil colony formation in agar, the ultrastructure of neutrophils, and neutrophil chemotaxis were normal recovered from the neutropenia between 11 and 30 months of age. These in vitro parameters appear to be useful for evaluating chronic neutropenia of childhood.<\/jats:p>","DOI":"10.1002\/ajh.2830110209","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:36:36Z","timestamp":1172039796000},"page":"175-182","source":"Crossref","is-referenced-by-count":8,"title":["Morphologic and functional heterogeneity of chronic neutropenia of childhood with normal neutrophil colony formation in vitro"],"prefix":"10.1002","volume":"11","author":[{"given":"A.","family":"Komiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Morosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Akabane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90409-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197011122832002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1182\/blood.V44.1.33.33","article-title":"Analysis of interacting cell populations in cultures of marrow from patients with neutropenia","volume":"44","author":"Senn JS","year":"1974","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1182\/blood.V46.5.723.723","article-title":"Congenital neutropenia; neutrophil proliferation with abnormal maturation","volume":"46","author":"Parmley RT","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1542\/peds.59.5.739","article-title":"Evaluation of neutropenic disorders by in vitro bone marrow culture","volume":"59","author":"Falk PM","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1182\/blood.V49.3.425.425","article-title":"Congenital neutropenia; an intrinsic cell defect demonstrated by electron microscopy of soft agar colonies","volume":"49","author":"Zucker\u2010Franklin D","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80343-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V56.3.465.465"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92679-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040760111"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92493-3"},{"key":"e_1_2_1_13_2","first-page":"10","volume-title":"Smith's Blood Diseases of Infancy and Childhood","author":"Miller DR","year":"1978"},{"key":"e_1_2_1_14_2","first-page":"467","article-title":"Transient \u201clazy\u2010leukocyte\u201d syndrome during infancy","volume":"134","author":"Yoda S","year":"1980","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1182\/blood.V23.3.359.359","article-title":"Chronic granulocytopenia in childhood","volume":"23","author":"Zuelzer WW","year":"1964","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80377-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb00815.x"},{"issue":"105","key":"e_1_2_1_18_2","first-page":"1","article-title":"Infantile genetic agranulocytosis (granulocytosis infantilis hereditaria): New recessive lethal disease in man","volume":"45","author":"Kostmann R","year":"1956","journal-title":"Acta Paediatr"},{"key":"e_1_2_1_19_2","first-page":"278","article-title":"Specific inhibitory activity against granulocyte\u2010progenitor cells produced by non\u2010T lymphocytes from patients with neutropenia","volume":"8","author":"Broxmeyer HE","year":"1980","journal-title":"Exp Hematol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830110209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830110209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:42:46Z","timestamp":1699832566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830110209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,9]]}},"alternative-id":["10.1002\/ajh.2830110209"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830110209","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}