{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:45:24Z","timestamp":1764053124439},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8988,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010five patients with refractory anemia with excess blasts (RAEB) were studied. Five of these patients showed Auer rods in their myeloblasts, but met other criteria for RAEB. Median survival of the Auer rod\u2010positive group was 14 months (range 2\u201327) from diagnosis with survival of 7 months after Auer rods were first observed. Median survival for the Auer rod\u2010negative group was 12 months. Two patients developed overt acute leukemia, both from the Auer rod\u2010negative group. The clinical course of Auer rod\u2010positive RAEB, like that of Auer rod\u2010negative RAEB, was one of progressive bone marrow failure complicated by infection, serious bleeding and the development of absolute transfusion requirement. These findings suggest that Auer rod\u2010positive RAEB is a morphologic variant dysmyelopoietic syndrome that may pursue a similar clinical course to Auer rod\u2010negative disease. Formulation of a separate treatment approach for those RAEB patients who possess Auer rods would appear ill advised.<\/jats:p>","DOI":"10.1002\/ajh.2830110408","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T06:30:50Z","timestamp":1172039450000},"page":"397-402","source":"Crossref","is-referenced-by-count":19,"title":["Auer rod positive dysmyelopoietic syndrome"],"prefix":"10.1002","volume":"11","author":[{"given":"Daniel J.","family":"Weisdorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin M.","family":"Oken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Rydell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-6-740"},{"key":"e_1_2_1_4_2","volume-title":"Leukemia","author":"Gunz F","year":"1970"},{"key":"e_1_2_1_5_2","first-page":"809","volume-title":"Hematology","author":"Henderson ES","year":"1977"},{"key":"e_1_2_1_6_2","first-page":"33","article-title":"Preleukemic states","volume":"2","author":"Dreyfus B","year":"1976","journal-title":"Blood Cells"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<1976::AID-CNCR2820440603>3.0.CO;2-#"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.127.5.910"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196304112681504"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1953.03690110032010"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.132.2.226"},{"key":"e_1_2_1_12_2","first-page":"73","article-title":"Preleukemia states","volume":"11","author":"Pierre RV","year":"1974","journal-title":"Semin Hematol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90148-4"},{"key":"e_1_2_1_14_2","first-page":"341","article-title":"Les myeloblastoses partielles","volume":"61","author":"Izrael V","year":"1974","journal-title":"Bull Cancer"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(79)90006-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb08808.x"},{"key":"e_1_2_1_17_2","first-page":"81","article-title":"Preleukemia: Does it exist?","volume":"2","author":"Killman SA","year":"1976","journal-title":"Blood Cells"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(79)90007-9"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830110408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830110408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:51:41Z","timestamp":1699833101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830110408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,12]]}},"alternative-id":["10.1002\/ajh.2830110408"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830110408","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12]]}}}