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Peripheral blood T lymphocytes isolated from three patients in the early recovery phase of IM were mixed with their autologous EBV\u2010infected B cells. Motile lymphocytes with their characteristic hand mirror shape were observed to attach by their uropods to the B cells. The HML remained attached for variable periods ranging from 45\u201075 min. Following detachment, B cells that were in contact with HML underwent lysis. Mixtures of T cells from healthy donors and EBV\u2010infected cell lines exhibited only rare uropod formation with no attachment or lysis of B cells. The present experiment indicates that contact\u2010induced lysis of EBV\u2010infected B lymphocytes is operative in IM and that this process is mediated by the HML.<\/jats:p>","DOI":"10.1002\/ajh.2830120203","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:39:24Z","timestamp":1172043564000},"page":"109-119","source":"Crossref","is-referenced-by-count":4,"title":["Morphologic observations of contact\u2010induced lysis of EBV\u2010infected B lymphocytes by autologous hand mirror T cells"],"prefix":"10.1002","volume":"12","author":[{"given":"William J.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Duval\u2010Arnould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Creegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold 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