{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:53:24Z","timestamp":1790877204733,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8867,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kinetics andw quantification of the sites of destruction of <jats:sup>111<\/jats:sup>\u2010Indium\u2010oxine\u2010labeled autologous platelets were investigated in eight patients with idiopathic thrombocytopenic purpura. The mean platelet count was 17 \u00b1 9 \u00d7 10<jats:sup>9<\/jats:sup>\/liter; platelets were separated by differential centrifugation and labeled with 5.6 \u00b1 2.5 MBq <jats:sup>111<\/jats:sup>In. Whole body and organ <jats:sup>111<\/jats:sup>In\u2010platelet distribution was quantitated with a scintillation camera and a computer\u2010assisted imaging system acquisition matrix. Areas of interest were selected with the computer and organ <jats:sup>111<\/jats:sup>In\u2010radioactivity expressed as a percentage of whole body activity. Mean platelet survival was 49.5 \u00b1 29.6 hr and the survival curves were exponential. Equilibrium percentage organ <jats:sup>111<\/jats:sup>In\u2010radioactivity was (normal values in parentheses): spleen 33.7 \u00b1 8.8(31.1 \u00b1 10.2); liver 16.1 \u00b1 9.5(13.1 \u00b1 1.3); thorax 22.8 \u00b1 3.7(28.2 \u00b1 5.6). Percentage organ <jats:sup>111<\/jats:sup>In\u2010activity at the time when labeled platelets had disappeared from the circulation was: spleen 44.5 \u00b1 16.4 (40 \u00b1 16); liver 16.0 \u00b1 11.5 (32.4 \u00b1 7.2); thorax 19.7 \u00b1 6.0 (17.7 \u00b1 10.3). Thorax activity corresponds to bone marrow radioactivity. Three patterns of platelet sequestration were evident. Three patients had mainly splenic sequestration, two mainly hepatic sequestration, and three diffuse reticuloendothelial system sequestration with a major component of platelets destroyed in the bone marrow. Splenectomy was performed in two patients. The pattern of <jats:sup>111<\/jats:sup>In\u2010platelet sequestration was not predictive of response of glucocorticoid therapy or indicative of the necessity for splenectomy. Quantitative <jats:sup>111<\/jats:sup>In\u2010labeled autologous platelet kinetic studies provide a new tool for the investigation of platelet disorders.<\/jats:p>","DOI":"10.1002\/ajh.2830120209","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:39:24Z","timestamp":1172043564000},"page":"167-177","source":"Crossref","is-referenced-by-count":67,"title":["Kinetics and sites of destruction of <sup>111<\/sup>indium\u2010oxine\u2010labeled platelets in idiopathic thrombocytopenic purpura: A quantitative study"],"prefix":"10.1002","volume":"12","author":[{"given":"A. Dup.","family":"Heyns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"L\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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