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Her bone marrow and peripheral blood cells cultured in vitro were able to produce normal numbers of eosinophil colonies. The present disorder was thus not caused by a lack of EO\u2010CFU\u2010C, nor by a defect in EO\u2010CSA, nor by an immunologically mediated mechanism acting on mature or immature eosinophils or on EO\u2010CSA producing cells. It is suggested that the marrow was not able to differentiate normally along the eosinophil pathway, possibly owing to a microenvironmental defect or, less likely, an intrinsic stem cell defect.<\/jats:p>","DOI":"10.1002\/ajh.2830120211","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:39:24Z","timestamp":1172043564000},"page":"187-197","source":"Crossref","is-referenced-by-count":4,"title":["A case of chronic aneosinocytosis"],"prefix":"10.1002","volume":"12","author":[{"given":"Adam","family":"Telerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Amson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Delforge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Collard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre A.","family":"Stryckmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Clinical Hematology","author":"Wintrobe MM","year":"1974"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105502"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92440-0"},{"key":"e_1_2_1_5_2","first-page":"48","volume-title":"Diagnostic Laboratory Hematology","author":"Cartwright GE","year":"1968"},{"key":"e_1_2_1_6_2","unstructured":"GilbertHS AnsleyH:Application of automated cytochemical techniques to the characterization of leukemic cells. 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