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The data indicate that the mild anemia of hemoglobin (Hb) SC disease is slightly microcytic and hyperchromatic. Parameters of hemolysis and the complications of chronic hemolytic anemia (cholelithiasis, leg ulcers, hepatomegaly, and cardiomegaly) are milder in Hb SC disease than in sickle cell anemia. Asplenia and its sequelae (increased platelet count and reduced serum IgM levels) are less frequent in Hb SC disease. Cerebrovascular accidents and the decreased leukocyte alkaline phosphatase scores are similar in both diseases. Thromboembolic complications, retinopathy, and renal papillary necrosis are more frequent in Hb SC disease.<\/jats:p>","DOI":"10.1002\/ajh.2830130106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:36:11Z","timestamp":1172043371000},"page":"37-51","source":"Crossref","is-referenced-by-count":73,"title":["Clinical, hematological, and biochemical features of Hb SC disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Samir K.","family":"Ballas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia N.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Noone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven 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