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The 8\u2010year\u2010old son of the proband also had hereditary spherocytosis and mildly increased iron stores. The 39\u2010year\u2010old brother of the proband did not have spherocytosis but did have overt hemochromatosis. Since hemochromatosis is transmitted as an HLA\u2010linked autosomal recessive disorder, HLA haplotypes serve as markers of hemochromatosis alleles. In this pedigree only individuals with two hemochromatosis alleles (homozygosity) had heavy iron loads, whether hereditary spherocytosis was present or not. The presence of hereditary spherocytosis may have contributed to the magnitude of the iron loading but was not a major factor. Our findings suggest that nontransfusional hemochromatosis found in association with hereditary spherocytosis is due primarily to homozygosity for hemochromatosis.<\/jats:p>","DOI":"10.1002\/ajh.2830130202","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:35:59Z","timestamp":1172043359000},"page":"101-109","source":"Crossref","is-referenced-by-count":28,"title":["Iron overload in hereditary spherocytosis: Association with hla\u2010linked hemochromatosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Corwin Q.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Skolnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Dadone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(49)92301-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(53)90024-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.120.6.701"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90648-X"},{"key":"e_1_2_1_6_2","first-page":"9","article-title":"Hereditary spherocytosis, haemochromatosis, diabetes mellitus, and chondroacalcinosis","volume":"66","author":"Berry EM","year":"1973","journal-title":"Proc R Soc Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.140.7.983"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb07204.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707072970102"},{"key":"e_1_2_1_10_2","first-page":"43","article-title":"Hereditary hemochromatosis: Contributions of genetic analyses","volume":"12","author":"Edwards CQ","year":"1981","journal-title":"Prog Hematol"},{"key":"e_1_2_1_11_2","first-page":"797","volume-title":"Manual of Clinical Immunology","author":"Amos DB","year":"1976"},{"key":"e_1_2_1_12_2","first-page":"238","article-title":"Hemochromatose idiopathique. 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