{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:44:02Z","timestamp":1775065442141,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8714,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1982,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The quantity and the rate of synthesis of fetal hemoglobin (HbF); the level of HbF\u2010containing erythrocytes (F cells); and the levels of progesterone, human chorionic gonadotropin (HCG), and human chorionic somatomammotropin (HCS) in serial blood samples from women at different stages of pregnancy were determined. An increase was observed in the synthesis and the quantity of maternal HbF, reaching a peak at about 9\u201312 weeks gestation. A major peak in F\u2010cell level was also detected at about 9\u201312 weeks, with two minor peaks appearing at about 16\u201320 and 22\u201324 weeks. Levels of HCG, HCS, and progesterone also varied during pregnancy. Timing of the rise and fall of HCG levels corresponded to that of maternal HbF levels, whereas levels of HCS and progesterone did not reach their peak until later stages of gestation when HbF level had returned to normal.<\/jats:p><jats:p>Similar analysis conducted on patients with hydatidiform molar pregnancy revealed that the majority (&gt;95%) of these patients showed significant increases in HbF synthesis at the time of molar evacuation, but decreased to normal levels in approximately 30 days postevacuation. A similar profile in the levels of HCG, but not progesterone and HCS, was observed. A positive correlation between levels of HCG and HbF can be established (correlation coefficient = 0.94). These data are in agreement with the hypothesis that HCG may act as a stimulus for the enhanced HbF synthesis in adults.<\/jats:p>","DOI":"10.1002\/ajh.2830130205","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:35:59Z","timestamp":1172043359000},"page":"131-139","source":"Crossref","is-referenced-by-count":8,"title":["Fetal hemoglobin in women with normal and with hydatidiform molar pregnancy"],"prefix":"10.1002","volume":"13","author":[{"given":"John C.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marguerite K.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"43","article-title":"Developmental biology of human hemoglobins","volume":"10","author":"Wood WG","year":"1977","journal-title":"Prog Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90106-X"},{"key":"e_1_2_1_4_2","first-page":"1092","article-title":"Immunological studies of hemoglobins. 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