{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T04:10:46Z","timestamp":1707624646329},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8472,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In vitro lymphocyte functions in a patient with Waldenstr\u00f6m's macroglobulinemia and his kindred were examined. The percentage and number of total peripheral blood T cells and the absolute number of FC\u03b3 bearing T cells were decreased in the patient and family members compared to controls but the B cells and monocytes were normal. In addition, PHA and PWM stimulated proliferation were decreased. Decreased responsiveness to PWM was abrogated by preculturing PBMC in media alone before PWM stimulation. Decreased responsiveness to PHA was not reversed by a similar period of preculture.<\/jats:p><jats:p>To further define the above abnormalities in immunoregulation we examined mononuclear subpopulations. In controls, adding purified T cells or Con A activated lymphocytes to autologous cultures which had been stimulated with PHA and PWM significantly decreased proliferative activity. No such suppressive activity of T cells or Con A activated cells from the patient or family members was noted.<\/jats:p><jats:p>These data demonstrate an absent or functionally inactive spontaneous and Con A activated T suppressor cells in the family of a patient with Waldenstr\u00f6m's macroglobulinemia.<\/jats:p>","DOI":"10.1002\/ajh.2830140303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:50:47Z","timestamp":1172044247000},"page":"215-225","source":"Crossref","is-referenced-by-count":0,"title":["Altered Immunoregulation in Waldenstr\u00f6m's macroglobulinemia. I. The absence of con A\u2010induced and spontaneous T suppressor cell activity in a patient and his kindred"],"prefix":"10.1002","volume":"14","author":[{"given":"Robert H.","family":"Keller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Libnoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.0954-6820.1944.tb03955.x","article-title":"Incipient myelomatosis or essential hyperglobulinemia with fibrinogenopenia: New syndrome","volume":"117","author":"Waldenstr\u00f6m J","year":"1944","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/archinte.1975.00330010064009","article-title":"Monoclonal gammopathies in lymphomas","volume":"135","author":"Alexanian R","year":"1975","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-5802-5_5"},{"key":"e_1_2_1_5_2","unstructured":"LukesRJ CollinsRD: New approaches to the classification of the lymphomate.Br J Cancer(Suppl 11):1\u201328 1975."},{"key":"e_1_2_1_6_2","first-page":"201","article-title":"Immunoregulatory abnormalities in chronic lymphatic leukemia. 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