{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:10:18Z","timestamp":1774789818816,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8441,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent advances about hereditary disorders of red cell enzymes in the Embden\u2010Meyerhof glycolytic pathway and Rapoport\u2010Luebering cycle are discussed with a stress on pyruvate kinase deficiency, because it is the most common and most intensively studied disorder among them. Broad genetic heterogeneity exists in all the known erythroenzymopathies. Recently, the primary structure of normal human red cell phosphoglycerate kinase has been determined and single amino acid substitutions of four mutant phosphoglycerate kinases have been clarified by Yoshida et al. These studies allowed analysis of structure\u2010function relationships at the molecular level to be carried out more precisely than was previously possible. It is the consensus of the investigators working in this field that the pathogenesis in three\u2010quarters of the congenital nonspherocytic hemolytic anemia patients remains unknown even after adequate red cell enzyme studies and isopropanol test for unstable hemoglobin have been done. This simply means that much studies remain to be worked out in this field.<\/jats:p>","DOI":"10.1002\/ajh.2830140410","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T09:54:31Z","timestamp":1172051671000},"page":"381-391","source":"Crossref","is-referenced-by-count":13,"title":["Hereditary disorders of red cell enzymes in the embden\u2010meyerhof pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Shiro","family":"Miwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"100","article-title":"Specific erythrocyte glycolytic enzyme defect (pyruvate kinase) in three subjects with congenital nonspherocytic hemolytic anemia","volume":"74","author":"Valentine WN","year":"1961","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2457-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0308-2261(21)00209-5","article-title":"Pyruvate kinase deficiency and other enzymopathies of the Embden\u2010Meyerhof pathway","volume":"10","author":"Miwa S","year":"1981","journal-title":"Clin Haematol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01733168"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109218"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(71)90095-7"},{"key":"e_1_2_1_8_2","first-page":"228","article-title":"Studies on erythrocyte metabolism in a case with hereditary deficiency of H\u2010subunit of lactate dehydrogenase","volume":"34","author":"Miwa S","year":"1971","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90013-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb03751.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07181.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630268008997731"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.5175"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a129852"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(78)90009-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90245-6"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/292070a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb01809.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.117.179"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1182\/blood.V56.5.902.902","article-title":"Pyruvate kinase hyperactivity genetically determined: Metabolic consequences and molecular characterization","volume":"56","author":"Max\u2010Audit I","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_21_2","first-page":"549","volume-title":"Proceedings of the Tenth International Congress on Blood Transfusion, Stockholm, 1964","author":"Z\u00fcrcher C","year":"1965"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb02121.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90036-2"},{"key":"e_1_2_1_24_2","first-page":"525","article-title":"Sequestration and destruction of reticulocytes in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia","volume":"35","author":"Matsumoto N","year":"1972","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_25_2","first-page":"46","article-title":"Fine structure of the spleen and liver in glucosephosphate isomerase (GPI) deficiency hereditary nonspherocytic hemolytic anemia. Selective reticulocyte destruction as a mechanism of hemolysis","volume":"36","author":"Matsumoto N","year":"1973","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106539"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830070302"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00941.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1700039"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196701052760101"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830100202"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273980"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01008661"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830090102"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.4.629.629"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830120303"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1182\/blood.V54.2.389.389","article-title":"Phosphofructokinase in human blood cells","volume":"54","author":"Meienhofer M\u2010C","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_38_2","first-page":"154","article-title":"Red cell aldolase deficiency and hemolytic anemia: A new syndrome","volume":"86","author":"Beutler E","year":"1974","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830110412"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(77)90094-1"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283637"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1016\/S0021-9258(18)43753-2","article-title":"Complete amino acid sequence of human phosphoglycerate kinase. Isolation and amino acid sequence of tryptic peptides","volume":"255","author":"Huang O\u2010Y","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_43_2","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1016\/S0021-9258(18)43754-4","article-title":"Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence","volume":"255","author":"Huang I\u2010Y","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_44_2","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1016\/S0021-9258(18)43755-6","article-title":"A single amino acid substitution (Asp\u2010Asn) in a phosphoglycerate kinase variant (PGK M\u00fcnchen) associated with enzyme deficiency","volume":"255","author":"Fujii H","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5461"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2587"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/279773a0"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(73)91347-8"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1975.tb09899.x"},{"key":"e_1_2_1_50_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V54.1.1.1","article-title":"Red cell enzyme defects as nondiseases and as disease","volume":"54","author":"Beutler E","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630268008997749"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb00589.x"},{"key":"e_1_2_1_53_2","volume-title":"A Manual of Biochemical Methods","author":"Beutler E","year":"1978"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a128240"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830140410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830140410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T08:18:47Z","timestamp":1697789927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830140410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1002\/ajh.2830140410"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830140410","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}