{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:40:16Z","timestamp":1695890416010},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8349,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of splenic congestion associated with acute hemolytic anemia on susceptibility to bacterial infection was investigated in rats inoculated with Haemophilus influenzae b by intranasal (in) or intravenous (iv) challenge. The rats were made anemic by phenylhydrazine treatment and were challenged with 10<jats:sup>6<\/jats:sup> (in) or 5 \u00d7 10<jats:sup>7<\/jats:sup> (iv) H influenzae b. Forty\u2010eight hours after in inoculation of bacteria, the number of bacteria in the blood was 10 times greater in the anemic rats with extensive splenic congestion than in controls. After iv inoculation of bacteria, a significantly (P &lt; 0.001) higher mortality rate was found in the anemic rats with extensive splenic congestion and fewer bacteria were present in the spleens but not the livers, as compared to normal rats. Since phenylhydrazine\u2010induced hemolytic anemia exhibited an extensive congestion in the spleen, higher mortality rate observed in the anemic rats challenged with H influenzae b may result, in part, from decreased intravascular clearance of bacteria by the spleen.<\/jats:p>","DOI":"10.1002\/ajh.2830150203","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T09:46:22Z","timestamp":1172051182000},"page":"117-121","source":"Crossref","is-referenced-by-count":4,"title":["Effect of splenic congestion associated with hemolytic anemia on mortality of rats challenged with haemophilus influenzae b"],"prefix":"10.1002","volume":"15","author":[{"given":"L. T.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. R.","family":"Moxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood.V56.4.737.737","article-title":"Intrasplenic microcirculation in rats with acute hemolytic anemia","volume":"56","author":"Chen LT","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110168"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.2.154"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/135.2.303"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/iai.27.3.872-875.1980","article-title":"Haemophilus influenzae b infection in rats: Effect of splenectomy on blood stream and meningeal invasion after intravenous and intranasal inoculations","volume":"27","author":"Moxon ER","year":"1980","journal-title":"Infect Immun"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.4.517"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1016\/S0021-9258(18)34576-9","article-title":"Impaired adenylate cyclase activity of phenylhydrazine\u2010induced reticulocytes","volume":"275","author":"Cooper DM","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_9_2","first-page":"507","article-title":"Blood flow and phagocytic activity of the spleen of the rat with acute hemolytic anemia","volume":"22","author":"Chen LT","year":"1977","journal-title":"J Reticuloendoth Soc"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.37.1.111","article-title":"The role of the spleen in immunity: With special reference to the post\u2010splenectomy problem in infants","volume":"37","author":"Ellis EF","year":"1966","journal-title":"Pediatrics"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830150203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830150203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T05:51:56Z","timestamp":1695793916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830150203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,9]]}},"alternative-id":["10.1002\/ajh.2830150203"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830150203","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}