{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:25:54Z","timestamp":1756463154933},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8106,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three patients with idiopathic pancytopenia and hypercellular bone marrow who developed carcinoma of the lung within two years of diagnosis are reported. All three patients had macrocytic anemia associated with a megaloblastic marrow in the presence of normal serum vitamin B12 and folic acid levels. Neutropenia with monocytosis, elevated serum muramidase and LAP scores, and increased fetal hemoglobin levels were also found. In all cases Ham's tests were negative with a normal bone marrow karyotype. In all three patients, pancytopenia due to myelodysplasia, a probable preleukemic state, was diagnosed initially prior to the appearance of carcinoma of the lung.<\/jats:p><jats:p>One of the patients showed improved leukocyte and platelet counts during chemotherapy, while the other two died before chemotherapy could be administered. In the light of the above findings we suggest that carcinoma of the lung may be the cause of a paraneoplastic syndrome with pancytopenia, particularly in patients with a hypercellular marrow with a normal karyotype.<\/jats:p>","DOI":"10.1002\/ajh.2830160411","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T09:38:21Z","timestamp":1172050701000},"page":"403-408","source":"Crossref","is-referenced-by-count":13,"title":["Pancytopenia with hypercellular bone marrow\u2014a possible paraneoplastic syndrome in carcinoma of the lung: A report of three cases"],"prefix":"10.1002","volume":"16","author":[{"given":"Itamar","family":"Raz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilat","family":"Shinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"19","article-title":"Hematological and biochemical paraneoplastic disorders","volume":"102","author":"Payan HM","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-5029(79)80013-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1967.tb08854.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb14450.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1749-6632.1974.tb14451.x","article-title":"Granulocytosis in neoplasia","volume":"230","author":"Robinson WA","journal-title":"Ann NY Acad Sci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb14452.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1749-6632.1974.tb14453.x","article-title":"Paraneoplastic syndrome associated with monoclonal lymphocyte and plasma cell proliferation","volume":"230","author":"Salmon SE","journal-title":"Ann NY Acad Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb14471.x"},{"key":"e_1_2_1_10_2","first-page":"428","article-title":"Importance of paraneoplastic bone marrow and blood picture findings","volume":"86","author":"Helbig W","year":"1970","journal-title":"Verh Dtsch Ger Inn Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195901\/02)12:1<47::AID-CNCR2820120110>3.0.CO;2-Q"},{"key":"e_1_2_1_12_2","first-page":"2372","article-title":"Paraneoplastic syndrome in der inneren medizin","volume":"27","author":"Pusch HJ","year":"1976","journal-title":"Med Welt"},{"key":"e_1_2_1_13_2","first-page":"2053","article-title":"Das paraneoplastische syndrome","volume":"70","author":"Thomas C","year":"1975","journal-title":"Med Klin"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/ajcp\/65.3.344","article-title":"Pancytopenia associated with granulosa cell tumor of the ovary","volume":"65","author":"Napoli VM","year":"1976","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_15_2","first-page":"548","article-title":"Metastases in bone marrow and pancytopenia from carcinoma of the lung","volume":"43","author":"Law IP","year":"1973","journal-title":"Med Ann DC"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90781-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood.V54.2.530.530","article-title":"Two cases of carcinoma of the lung characterized by a bone marrow agar culture pattern resembling acute myeloid leukemia","volume":"54","author":"McCarthy JH","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2 <854::AID-CNCR2820420707>3.0.CO;2-W"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-2-347"},{"key":"e_1_2_1_20_2","first-page":"5","article-title":"Preleukemic states","volume":"2","author":"Bernard J","year":"1976","journal-title":"Blood Cells"},{"key":"e_1_2_1_21_2","first-page":"11","article-title":"The preleukemic syndrome: Clinical and laboratory features, natural course, and management","volume":"2","author":"Linman JW","year":"1976","journal-title":"Blood Cells"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90148-4"},{"key":"e_1_2_1_23_2","first-page":"33","article-title":"Preleukemic states: I. 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