{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:37:27Z","timestamp":1697866647365},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":8106,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient with T\u2010cell prolymphocytic leukemia (T\u2010PLL) is described. The malignant T\u2010cells from the patient were predominantly Leu\u20102\u2010positive, indicating a suppressor phenotype. The cells were then tested to determine their functional capabilities. The patient's Leu\u20102\u2010positive cells initially suppressed B\u2010cell proliferation, as predicted by their phenotype but later functioned as T helper cells in the pokeweed mitogen system without a change in phenotype. The cells also responded inadequately to alloantigen and mitogen despite addition of exogenous T\u2010cell growth factor (TCGF). Leu\u20102\u2010positive prolymphocytes from the spleen of the patient were constitutive producers of TCGF. Surface phenotype using monoclonal antibody was inadequate to predict T\u2010cell function of the cells from this patient with T\u2010PLL. In addition, these data suggest there may be functional subpopulations within the OKT8 + phenotype. Constitutive TCGF production by malignant post\u2010thymic T\u2010cells may represent a mechanism by which these cells sustain their own growth.<\/jats:p>","DOI":"10.1002\/ajh.2830160412","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T09:38:21Z","timestamp":1172050701000},"page":"409-417","source":"Crossref","is-referenced-by-count":7,"title":["Functional diversity within the suppressor phenotype as defined by monoclonal antibody in T\u2010cell prolymphocytic leukemia"],"prefix":"10.1002","volume":"16","author":[{"given":"Kenneth W.","family":"Zamkoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Poiesz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis W.","family":"Ruscetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio T.","family":"Planas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Lamberson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0308-2261(21)00561-0","article-title":"Hairy cell leukemia and prolymphocytic leukemia","volume":"6","author":"Catovsky D","year":"1977","journal-title":"Clin Haematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06769.x"},{"key":"e_1_2_1_4_2","first-page":"736","article-title":"Multiparameter studies in lymphoid leukemias","volume":"72","author":"Catovsky D","year":"1979","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/77.5.643"},{"key":"e_1_2_1_6_2","first-page":"193","article-title":"T\u2010cell prolymphocytic leukemia with a suppressor phenotype","volume":"13","author":"Planas AT","year":"1983","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.128.3.1386","article-title":"Functional analysis of human T cell subsets defined by monoclonal antibodies. 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