{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:42:14Z","timestamp":1754109734030},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7892,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1984,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 56\u2010year\u2010old man developed procainamide\u2010induced agranulocytosis. Bone marrow aspiration showed the absence of myeloid elements beyond the promyelocyte stage. Procainamide at therapeutic concentrations in vitro depressed bone marrow granulocyte\u2010macrophage colonies (CFUc) while CFUc growth was normal in the absence of drug. Following the patient's recovery, CFUc growth was no longer suppressed by procainamide in vitro. The observations in this patient showing reversible sensitivity to drug contrast with those on other patients with drug\u2010induced agranulocytosis that show persistent marrow injury or drug sensitivity despite clinical recovery.<\/jats:p>","DOI":"10.1002\/ajh.2830170413","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:07:00Z","timestamp":1172052420000},"page":"427-432","source":"Crossref","is-referenced-by-count":5,"title":["Procainamide\u2010induced agranulocytosis with reversible myeloid sensitivity"],"prefix":"10.1002","volume":"17","author":[{"given":"John C.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Lutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur E.","family":"Fass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"850","article-title":"Fatal agranulocytosis resulting from a procaine derivative","volume":"38","author":"Miller H","year":"1951","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1951.73670240016006g"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(52)90247-0"},{"key":"e_1_2_1_5_2","first-page":"510","article-title":"Agranulocytose au cours d'un traitement par l'amide procainique","volume":"25","author":"Febregoule M","year":"1954","journal-title":"Le Sang"},{"key":"e_1_2_1_6_2","first-page":"655","article-title":"A case report, procaine amide hydrochloride (Pronestyl) induced agranulocyosis","volume":"64","author":"Talmers FN","year":"1965","journal-title":"J Mich Med Soc"},{"key":"e_1_2_1_7_2","first-page":"354","article-title":"Agranulocytosis and lupus erythematosus phenomenon after procainamide","volume":"2","author":"Oster LH","year":"1966","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(69)90024-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1969.tb05361.x"},{"key":"e_1_2_1_10_2","first-page":"107","article-title":"Desensitization to procainamide","volume":"67","author":"Ream CR","year":"1970","journal-title":"J Med Soc NJ"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92533-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/003693307201700501","article-title":"Agranulocytosis caused by procainamide","volume":"17","author":"Hickson B","year":"1972","journal-title":"Scot Med J"},{"key":"e_1_2_1_13_2","first-page":"87","article-title":"Agranulocytosis due to procainamide hydrochloride","volume":"23","author":"Dross VP","year":"1974","journal-title":"Md State Med J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287401300905"},{"key":"e_1_2_1_15_2","first-page":"S5","article-title":"Procainamide reactions","volume":"74","author":"Chelius CJ","year":"1975","journal-title":"Wis Med J"},{"key":"e_1_2_1_16_2","first-page":"1362","article-title":"Agranulocytosis associated with procainamide therapy. 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