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Other mechanisms have been postulated by other investigators. The therapeutic significance of increased Hb F levels in homozygous \u03b2 thalassemia and sickle cell anemia is exemplified. The potential risk of carcinogenicity has delayed more extensive clinical trials.<\/jats:p>","DOI":"10.1002\/ajh.2830170416","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:07:00Z","timestamp":1172052420000},"page":"439-447","source":"Crossref","is-referenced-by-count":12,"title":["5\u2010azacytidine and fetal hemoglobin"],"prefix":"10.1002","volume":"17","author":[{"given":"Paul","family":"Heller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Desimone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1182\/blood.V58.6.1057.1057","article-title":"Intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease","volume":"58","author":"Noguchi 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