{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:55:07Z","timestamp":1767664507211},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7802,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Splenic atrophy or evidence of hyposplenism occurs in as many as one third of all patients with S\u2010C hemoglobinopathy. Yet there are few reports in the literature of clinically apparent splenic infarction in this disease. We describe four instances of acute splenic infarction in three patients with hemoglobin S\u2010C disease which illustrate a wide spectrum of clinical manifestations and severity. Of particular interest were the observations of coincident occurrences of splenic sequestration and functional hyposplenism with splenic infarction, suggesting a close pathophysiological relationship among these syndromes.<\/jats:p>","DOI":"10.1002\/ajh.2830180307","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T18:36:16Z","timestamp":1224268576000},"page":"261-268","source":"Crossref","is-referenced-by-count":17,"title":["Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S\u2010C disease"],"prefix":"10.1002","volume":"18","author":[{"given":"David A.","family":"Sears","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Udden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"289","article-title":"Clinical features of the genetic variants of sickle cell disease","volume":"94","author":"Smith EW","year":"1954","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-195805000-00012"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1182\/blood.V18.4.385.385","article-title":"S\u2010C hemoglobin: A clinical study","volume":"18","author":"River GL","year":"1961","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01675.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830130106"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.25.1.49"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.136.8.905"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1954.02940360009003"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1954.02950100031010a"},{"key":"e_1_2_1_11_2","first-page":"35","article-title":"Sicklemia and infarction of the spleen during aerial flight. 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