{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:36:05Z","timestamp":1787999765705,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The response to infusions of cryoprecipitate and factor VIII concentrate was studied in a patient with platelet\u2010type von Willebrand disease (vWD) who showed lack of the large multimers of von Willebrand factor in plasma, increased platelet aggregation with low concentrations of ristocetin, and in vitro platelet aggregation by normal plasma. The cryoprecipitate and factor VIII concentrate to be infused induced platelet aggregation when added to patient platelet\u2010rich plasma at concentrations higher than 0.86 U\/ml and 3 U\/ml of factor VIII\u2010related antigen (VIIIR:Ag), respectively. Administration of cryoprecipitate (41.9 U VIIIR:Ag\/kg body weight) was followed by a shortening of the bleeding time, and hemostasis was achieved during tooth extractions. Factor VIII concentrate (70.2 U VIIIR:Ag\/kg) failed to correct the prolonged bleeding time and proved ineffective to control the gum bleeding. No significant diminution of the platelet count was observed following any infusion. These results indicate that cryoprecipitate is hemostatically effective and safe when infused in such a dosage, but factor VIII concentrate is not effective in platelet\u2010type vWD in analogy to what is observed in various types of vWD.<\/jats:p>","DOI":"10.1002\/ajh.2830180404","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:01:27Z","timestamp":1172052087000},"page":"351-362","source":"Crossref","is-referenced-by-count":5,"title":["Replacement therapy in platelet\u2010type von willebrand disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Hoyu","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830080308"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(80)90013-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202113060603"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1182\/blood.V60.3.790.790","article-title":"Platelet\u2010type von Willebrand's disease: Characterization of a new bleeding disorder","volume":"60","author":"Miller JL","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_6_2","unstructured":"TakahashiH NagayamaR HattoriA ShibataA:Von Willebrand's disease with increased ristocetin\u2010induced platelet aggregation: Increased binding affinity of the platelets for factor VIII.Symposium on Factor VIII\/von Willebrand Factor San Diego 1982 p26."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111112"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1910.04330140029009"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-0609.1970.tb01917.x","article-title":"Platelet adhesiveness in von Willebrand's disease. 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