{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:31Z","timestamp":1786976791744,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have characterized another subset of acute nonlymphocytic leukemia (ANLL) based on the cytogenetic and morphologic findings in a group of nine patients. Five patients had chromosomal analyses performed at the University of Chicago, two patients were studied at the All\u2010Union Cancer Research Center in Moscow, and one patient each was studied at the University of Maryland and at Fairfax Hospital in Fairfax, Virginia. All nine patients had a reciprocal translocation involving the short arm of chromosome 6 and the long arm of chromosome 9 [t(6;9)(p23;q34)]. The patients, four males and five females, ranged in age from 5 to 51 years; the median age of 38 years is lower than that typically seen in ANLL. Only two of eight treated patients entered a complete remission. Classification of bone marrow morphology according to FAB Cooperative Group criteria revealed AML\u2010M1 in one patient, AML\u2010M2 in four, and AMMoL\u2010M4 in three. One patient had refractory anemia with excess blasts (RAEB) which evolved to AML\u2010M2. All bone marrow specimens showed severe myelodysplasia, with Auer rods present in seven of the nine cases. Of note was the particular prominence of bone marrow basophils (greater than 1%) in eight of the nine (89%) patients. Among 160 evaluable patients with ANLL de novo seen at the University of Chicago whose cells lacked a t(6;9), only five (3%) had greater than 1% basophils in the marrow aspirates. It is of interest that the breakpoint in 9q involves the same chromosomal band as that in the t(9;22) observed in chronic myelogenous leukemia (CML), in which increased basophils are a prominent feature. Thus, the association of the t(6;9) with increased bone marrow basophils in ANLL may provide additional insight into the chromosomal location of genes regulating the production and\/or maturation of basophils.<\/jats:p>","DOI":"10.1002\/ajh.2830180409","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:01:27Z","timestamp":1172034087000},"page":"393-403","source":"Crossref","is-referenced-by-count":79,"title":["Increased numbers of marrow basophils may be associated with a t(6;9) in ANLL"],"prefix":"10.1002","volume":"18","author":[{"given":"Marilyn G.","family":"Pearson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Vardiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet 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L.","family":"Prigogina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91415-5"},{"key":"e_1_2_1_3_2","first-page":"109","article-title":"Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia","volume":"16","author":"Rowley JD","year":"1973","journal-title":"Ann Genet"},{"key":"e_1_2_1_4_2","first-page":"The Second Inte","article-title":"Leuven, Belgium, October 2\u20136, 1979","volume":"2","year":"1980","journal-title":"Cancer Genet 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