{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:41:27Z","timestamp":1776177687417,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7680,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of oxygenated perfluorotributylamine (Fluosol\u201043) on the rheological properties of sickle (HbSS) erythrocytes have been determined by means of microviscometry and positive pressure cell filtration. Incubation of deoxygenated sickled erythrocytes (pO<jats:sub>2<\/jats:sub> = 30 mmHg) with oxygenated Fluosol\u201043 reduced the percentage of sickled erythrocytes from about 63 to 33%. Deoxygenation of 40% suspension of sickle erythrocytes in autologous plasma increased the viscosity by about 160% at shear rate of 1.15 sec<jats:sup>\u22121<\/jats:sup>. Incubation of the deoxygenated sickled erythrocytes with oxygenated Fluosol\u201043 significantly reduced the viscosity at the low shear rates. Filtration of 0.2% suspension of deoxygenated sickle erythrocytes through capillarysized Nuclepore filters showed high resistance at low flow rates. Oxygenated Fluosol\u201043 increased the deformability of HbSS erythrocytes and thereby reduced the resistance at flow rates less than 1 ml\/min. These data suggest that perfluorocarbons may be useful in reducing the propensity of hemoglobin S polymeriztion and sickling and thereby prevent tissue infarction in vaso\u2010occlusive crisis. Therefore, the concept of examining the potential application of perfluorochemicals for alleviating severe vasoocclusive events may be useful.<\/jats:p>","DOI":"10.1002\/ajh.2830190304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T09:58:52Z","timestamp":1172051932000},"page":"229-236","source":"Crossref","is-referenced-by-count":20,"title":["Perfluorocarbon compounds: Effects on the rheological properties of sickle erythrocytes in vitro"],"prefix":"10.1002","volume":"19","author":[{"given":"C. A.","family":"Reindorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kurantsin\u2010Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Allotey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3730.1755"},{"key":"e_1_2_1_3_2","first-page":"384","article-title":"Perfluorocarbons","volume":"27","author":"Geyer RP","year":"1968","journal-title":"Fed Proc"},{"key":"e_1_2_1_4_2","first-page":"1499","article-title":"\u201cBloodless\u201d rats through the use of artificial blood substitutes","volume":"34","author":"Geyer RP","year":"1975","journal-title":"Fed Proc"},{"key":"e_1_2_1_5_2","first-page":"297","article-title":"Successful complete replacement of the blood of living rats with artificial substitutes","volume":"32","author":"Geyer RP","year":"1973","journal-title":"Fed Proc"},{"key":"e_1_2_1_6_2","first-page":"1077","article-title":"Fluorocarbon\u2013polyol artificial blood substitutes. 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