{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:13:37Z","timestamp":1790820817915,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":7923,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010cell leukemia virus (HTLV\u2010I) is known to be associated with certain hematologic malignancies, and a related virus, HTLV\u2010III\/LAV, might be the cause of AIDS. Some persons with AIDS have had evidence of HTLV\u2010I infection. Unrelated to these findings, it has been suggested that HTLV\u2010I is transmitted via blood products. We therefore evaluated the serologic status to the HTLV\u2010I core antigen p24 of 48 persons with hemophilia (Hem A) receiving factor concentrate therapy (a group at risk for AIDS), 49 persons with \u03b2\u2010thalassemia major (Thal) receiving frozen packed red blood cells therapy (FPRC), 26 patients with sickle cell anemia (SCA) receiving FPRC, and 18 persons not receiving any blood products. All participants were clinically well; only one had a risk factor other than hemophilia for AIDS, and all were from New York City, an area with a high incidence of AIDS. No Hem A or nontransfused persons had serum antibody to HTLV core p24 antigen; three with Thal and one with SCA were antibody\u2010positive. These results were confirmed by both radioimmunoprecipitation and Western blot techniques. Positive serology did not correlate with any immune findings or quantity of blood products used. These data support that HTLV\u2010I is preferentially transmitted through cellular blood products and that it is an infection for which cellular blood product recipients in at least some areas of the United States are at risk. Concentrate products appear free of transmission risk relative to cellular blood products, but we cannot be certain that this safety is absolute. The public health implications of blood product transmission of HTLV\u2010I merit active, long\u2010term investigation.<\/jats:p>","DOI":"10.1002\/ajh.2830200205","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T17:01:21Z","timestamp":1224262881000},"page":"129-137","source":"Crossref","is-referenced-by-count":34,"title":["Human T\u2010cell leukemia virus (HTLV\u2010I) p24 antibody in New York City blood product recipients"],"prefix":"10.1002","volume":"20","author":[{"given":"Janine M.","family":"Jason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Steven","family":"McDougal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciril","family":"Cabradilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. S.","family":"Kalyanaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Evatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.3.406"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/294268a0"},{"key":"e_1_2_1_4_2","first-page":"406","article-title":"Detection of type C virus particles in short\u2010term cultured adult T\u2010cell leukemia cells","volume":"47","author":"Akagi T","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_1_5_2","first-page":"341","article-title":"A retrovirus associated with human adult T\u2010cell leukemia: In vitro activation","volume":"73","author":"Hinuma Y","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_6_2","first-page":"683","article-title":"HTLV: 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