{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:21:23Z","timestamp":1770967283750,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":7923,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have analyzed the distribution of terminal deoxynucleotidyl transferase (TdT) in 30 patients with myelodysplastic syndromes (MDS), in connection with morphology, cytochemistry, and cytogenetics. All cases in preleukemic phase were strictly TdT\u2010negative. At variance, 4 (19%) of 21 cases with subsequent leukemia were TdT\u2010positive and showed a pure lymphoid (one case) or a mixed lymphoid\u2010myelomonocytic (three cases) morphology. The TdT enzymatic activity ranged from 2 to 21 U\/10<jats:sup>8<\/jats:sup> cells and the percent of positive cells in the immunofluorescence test ranged from 10 to 80% of total. All cases were Philadelphia chromosome\u2010negative. The clonal origin of MDS from the pluripotent stem cell, capable of originating both a lymphoid and myeloid progeny, is further corroborated.<\/jats:p>","DOI":"10.1002\/ajh.2830200214","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T16:43:33Z","timestamp":1224261813000},"page":"187-190","source":"Crossref","is-referenced-by-count":6,"title":["Terminal deoxynucleotidyl transferase\u2010positive acute leukemias evolving from a myelodysplastic syndrome"],"prefix":"10.1002","volume":"20","author":[{"given":"E.","family":"Brusamolino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Isernia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. P.","family":"Alessandrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. I.","family":"Scovassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Bertazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1182\/blood.V54.6.1203.1203","article-title":"Terminal deoxynucleotidyl transferase as a hemopoietic cell marker","volume":"54","author":"Bollum FJ","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V60.3.685.685","article-title":"Prognostic significance of terminal transferase and adenosine deaminase in acute and chronic myeloid leukemia","volume":"60","author":"Bertazzoni U","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1200\/JCO.1984.2.8.871","article-title":"Clinical utility of terminal deoxynucleotidyl transferase and adenosine deaminase determinations in adult leukemia with a lymphoid phenotype","volume":"2","author":"Brusamolino E","year":"1984","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67984-1_10"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830090111"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830140110"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood.V44.3.449.449","article-title":"Hematopoietic stem cell theory in relation to lymphoblastic conversion of chronic myeloid leukemia","volume":"44","author":"Boggs DR","year":"1974","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3575-7_1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/274590a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1182\/blood.V64.1.318.318","article-title":"Simultaneous occurrence of terminal deoxynucleotidyl transferase and myeloperoxidase in individual leukemic blasts","volume":"64","author":"Lanham GR","year":"1984","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830200214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830200214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:10:59Z","timestamp":1695820259000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830200214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/ajh.2830200214"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830200214","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}