{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:58:31Z","timestamp":1697882311853},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":7923,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010dose arabinosyl cytosine (ARA\u2010C) was tested in 15 patients with acute leukemia after a myelodysplastic syndrome (MDS) and in six elderly patients with acute nonlymphoid leukemia (ANLL). The drug was given subcutaneously at 10 mg\/m<jats:sup>2<\/jats:sup>, every 12 hr for 2 weeks, every 28 days. The overall response rate was 19% (one complete remission, three partial responses), and the median duration of response was 4 months. No particular features at diagnosis were predictive of response. Pancytopenia and marrow hypoplasia occurred after 44 (78%) of 56 courses of therapy and were more severe in nonresponders. Four patients died during the aplasia following ARA\u2010C therapy. Subcutaneous low\u2010dose ARA\u2010C was of limited benefit and bore a noticeable hematologic toxicity.<\/jats:p>","DOI":"10.1002\/ajh.2830200215","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T16:43:13Z","timestamp":1224261793000},"page":"191-193","source":"Crossref","is-referenced-by-count":14,"title":["Low\u2010dose arabinosyl cytosine in acute leukemia after a myelodysplastic syndrome and in elderly leukemia"],"prefix":"10.1002","volume":"20","author":[{"given":"Emilio P.","family":"Alessandrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercole","family":"Brusamolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Lazzarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.9.3507"},{"key":"e_1_2_1_3_2","first-page":"774","article-title":"Induction of differentiation of human myeloid leukemia cells by inhibition of DNA synthesis","volume":"10","author":"Griffin J","year":"1982","journal-title":"Exp Hematol"},{"key":"e_1_2_1_4_2","first-page":"601","article-title":"Effects of chemotherapy for the dysmyelopoietic syndrome","volume":"65","author":"Armitage JO","year":"1981","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_5_2","first-page":"57","article-title":"Preleukemia: Is it leukemia already?","volume":"12","author":"Bernasconi C","year":"1984","journal-title":"Med Biol Environ"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb02771.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1182\/blood.V62.1.85.85","article-title":"Does treatment with ARA\u2010C in low dosage cause differentiation of leukemic cells?","volume":"63","author":"Castaigne S","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312293092602"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830200215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830200215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:09:45Z","timestamp":1695820185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830200215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/ajh.2830200215"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830200215","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}