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The extent of increased Ca uptake in the PNH red cells was related to the extent of increased sensitivity to complement, as judged by the sugar water test (p &lt; 0.001) and the acidified serum test (p &lt; 0.001), and inversely correlated to the decreased activity of red cell acetylcholinesterase (p &lt; 0.01). The results may indicate that increased calcium uptake in PNH red cells is a possible intrinsic defect of the red cell membranes in the disorder.<\/jats:p>","DOI":"10.1002\/ajh.2830200403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:19:09Z","timestamp":1172053149000},"page":"325-335","source":"Crossref","is-referenced-by-count":2,"title":["An increased calcium accumulation in ATP\u2010depleted red cells of the patients with paroxysmal nocturnal hemoglobinuria"],"prefix":"10.1002","volume":"20","author":[{"given":"Masaoo","family":"Shimoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Yawata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0308-2261(21)00632-9","article-title":"Paroxysmal nocturnal haemogtobinuria","volume":"4","author":"Sirchia G","year":"1975","journal-title":"Clin Haematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01657.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105388"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.3.549"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1182\/blood.V60.1.92.92","article-title":"Increased calcium permeability of cold\u2010stored erythrocyte","volume":"60","author":"Wiley JS","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106038"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(74)90062-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.12.4479"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(71)90185-4"},{"key":"e_1_2_1_11_2","first-page":"53","volume-title":"Membrane Transport in Red Cells","author":"Ferreira HG","year":"1977"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008658"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.65.1.84"},{"key":"e_1_2_1_14_2","first-page":"334","article-title":"Influency of temperature and method of centrifugation on the separation of erythrocytes","volume":"82","author":"Murphy JR","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_15_2","first-page":"78","volume-title":"Practical Haematology","author":"Dacie JV","year":"1975"},{"key":"e_1_2_1_16_2","first-page":"68","volume-title":"Red Cell Metabolism, A Manual of Biochemical Methods","author":"Beutler E","year":"1984"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V35.4.462.462"},{"key":"e_1_2_1_18_2","first-page":"304","volume-title":"Practical Haematology","author":"Dacie JV","year":"1975"},{"key":"e_1_2_1_19_2","first-page":"103","volume-title":"Red Cell Metabolism. 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