{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T08:24:01Z","timestamp":1718699041273},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7496,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we evaluated lymphocyte subpopulations in 23 adults with SCA. When compared to controls, SCA patients had higher lymphocyte counts with normal numbers of T101+ cells (T\u2010lymphocytes) and T4 + cells. T8+ cells were significantly increased in SCA patients in comparison to controls (1684 \u00b1 243 vs 980 \u00b1 367, p &lt; .001). This increment was largely dependent on a T101 \u2010, T8+ cell population. The SCA patients as a group had significantly decreased T4\/T8 ratio (p &lt; .0001). The SCA patients with history of blood transfusions had higher T4+ cells numbers and higher T4\/T8 ratio, but no other significant differences from nontransfused patients were noted. Our results are different from those reported for nontransfused children with SCA who showed normal T4\/T8 ratio.<\/jats:p><jats:p>Thus, a distinct pattern of abnormalities is seen in the lymphocyte subpopulations of adult SCA patients, unrelated to their exposure to blood transfusions.<\/jats:p>","DOI":"10.1002\/ajh.2830210104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:19:03Z","timestamp":1172053143000},"page":"23-27","source":"Crossref","is-referenced-by-count":19,"title":["Lymphocyte subpopulation abnormalities in sickle cell anemia: A distinctive pattern from that of AIDS"],"prefix":"10.1002","volume":"21","author":[{"given":"Oscar F.","family":"Ballester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge M.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda S.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92082-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-5-621"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-2-208"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-2-180"},{"key":"e_1_2_1_6_2","first-page":"9","article-title":"Lymphocyte blast transformation and peripheral lymphocyte percentage in patients with sickle cell anemia","volume":"10","author":"Glassman AB","year":"1980","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_1_7_2","first-page":"19","article-title":"Decreased natural killer cell activity in patients with zinc deficiency with sickle cell disease","volume":"105","author":"Tapazoglou E","year":"1985","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","first-page":"570A","article-title":"The \u201cNull\u201d lymphoid cell in sickle cell disease","volume":"24","author":"Frost P","year":"1976","journal-title":"Clin Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.4049\/jimmunol.125.2.725","article-title":"Human T cell antigens defined by monoclonal antibodies: The 65,000 dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin","volume":"125","author":"Royston I","year":"1980","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(80)90117-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-2-173"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.1.308.308"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197103000-00002"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-6-930"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304073081414"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830210104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830210104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:57:57Z","timestamp":1697882277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830210104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/ajh.2830210104"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830210104","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}