{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:01:39Z","timestamp":1770217299379,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7496,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28\u2010year\u2010old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PI<jats:sup>AI<\/jats:sup>\u2010positive and anti\u2010PI<jats:sup>AI<\/jats:sup> antibody could not be detected in serum obtained during the thrombocytopenic episode. Her serum was found to contain an antibody specific for a recently described platelet\u2010specific alloantigen, Bak<jats:sup>a<\/jats:sup>, in addition to multiple HLA\u2010specific antibodies. The patient's platelets, typed following recovery, were Bak<jats:sup>a<\/jats:sup>\u2010negative. These findings indicate that post\u2010transfusion purpura can occur in association with alloimmunization to platelet\u2010specific antigens other than PI<jats:sup>AI<\/jats:sup>.<\/jats:p><jats:p>In performing the serologic studies, a close relationship and possible identity between Bak<jats:sup>a<\/jats:sup> and another recently reported platelet antigen, Lek<jats:sup>a<\/jats:sup>, was observed. A method for analyzing mixtures of cytotoxic platelet\u2010reactive antibodies without separating the individual antibodies is described.<\/jats:p>","DOI":"10.1002\/ajh.2830210110","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:19:03Z","timestamp":1172053143000},"page":"79-88","source":"Crossref","is-referenced-by-count":38,"title":["Post\u2010transfusion purpura associated with alloimmunization against the platelet\u2010specific antigen, bak<sup>a<\/sup>"],"prefix":"10.1002","volume":"21","author":[{"given":"Rudolph M.","family":"Keimowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Aster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104383"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830090312"},{"key":"e_1_2_1_4_2","first-page":"274","volume-title":"Hemostasis","author":"Shulman NR","year":"1983"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1959.tb04032.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302033080526"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1983.tb01551.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb01960.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1982.tb00475.x"},{"key":"e_1_2_1_10_2","first-page":"413","article-title":"Post\u2010transfusion purpura","volume":"61","author":"Krueger S","year":"1976","journal-title":"Med J"},{"key":"e_1_2_1_11_2","first-page":"1285","article-title":"Post\u2010transfusion purpura cured by steroid therapy in a man","volume":"118","author":"Seidenfeld AM","year":"1978","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.45.2.241"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1980.tb135002.x"},{"issue":"3","key":"e_1_2_1_14_2","first-page":"728","article-title":"Post\u2010transfusion purpura as a gynecologic complication","volume":"55","author":"Rank BH","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01080184"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb07260.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1984.tb00047.x"},{"key":"e_1_2_1_18_2","first-page":"49","volume-title":"Immune Cytopenias (Methods in Hematology)","author":"Kunicki TJ","year":"1983"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood.V45.4.529.529","article-title":"Post\u2010transfusion purpura: A heterogenous syndrome","volume":"45","author":"Ziegler Z","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1980.tb01845.x"},{"key":"e_1_2_1_21_2","first-page":"3141","article-title":"The assessment of drug\u2010dependent and isoimmune anti\u2010platelet antibodies by the use of platelet aggregometry","volume":"51","author":"Deykin D","year":"1982","journal-title":"J Clin Invest"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb01108.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01089.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106084"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1973.tb00978.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1980.tb00196.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1969.tb04714.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196608042750503"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1182\/blood.V51.6.1197.1197","article-title":"Actively\u2010induced platelet\u2010bound IgG associated with thrombocytopenia in the marmoset","volume":"51","author":"Gengozian N","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(79)90100-7"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.4.834.834"},{"key":"e_1_2_1_32_2","volume-title":"Blood Cell Alloantigens\u2010An Update","author":"Aster RH","year":"1983"},{"issue":"1","key":"e_1_2_1_33_2","first-page":"179a","article-title":"Ability of PIAI\u2010negative platelets to acquire PIAI specificity from stored blood. A proposed mechanism to explain the autologous destruction of platelets in post transfusion thrombocytopenia","volume":"60","author":"Kickler TS","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_34_2","first-page":"222","article-title":"Platelet and leukocyte isoantigens and their antibodies: Serologic, physiologic, and clinical studies","volume":"4","author":"Shulman NR","year":"1964","journal-title":"Prog Hematol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197309000-00007"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.1.167.167"},{"key":"e_1_2_1_37_2","first-page":"510A","article-title":"Post\u2010transfusion purpura (PTP)\u2013A multifaceted enigma","volume":"27","author":"Hoak JC","year":"1979","journal-title":"Clin Res"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830210110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830210110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:58:27Z","timestamp":1697882307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830210110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/ajh.2830210110"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830210110","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}