{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:36:49Z","timestamp":1761237409483},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7376,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 20\u2010year\u2010old female from the Philippines developed anemia and granulocytopenia. With androgen therapy, her anemia improved but she continued to show a pattern of fluctuating neutropenia consistent with human cyclic neutropenia: Blood neutrophil oscillation was regular with a periodicity of 21 days. She developed recurrent pharyngitis and apthous stomatitis but there was no cycling of other blood elements. Bone marrow aspiration and biopsy showed normal developing myeloid cells, a clonal chromosomal abnormality, and myelofibrosis. During the fourth documented cycle, blasts appeared and complete lymphoblastic transformation ensued. Blast cells were CALLA positive, Ia positive, and contained intranuclear TdT; they were negative for E, EAC, and EA rosettes. She was treated for non\u2010T, non\u2010B CALLA\u2010positive ALL and within 6 weeks was in a remission without evidence of cycling neutrophil counts. This young woman's case suggests that cyclic neutropenia may represent a previously unrecognized premalignant state associated with acute lymphoblastic leukemia.<\/jats:p>","DOI":"10.1002\/ajh.2830220103","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:24:38Z","timestamp":1172053478000},"page":"9-16","source":"Crossref","is-referenced-by-count":9,"title":["Cyclic neutropenia as a premalignant manifestation of acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"22","author":[{"given":"Daniel B.","family":"Lensink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Barton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R.","family":"Appelbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"William P.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/blood.V36.2.254.254","article-title":"Computer simulation of granulopoeisis: Normal and impaired granulopoiesis","volume":"36","author":"King\u2010Smith EA","year":"1970","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107522"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1182\/blood.V51.5.941.941","article-title":"Unified hypothesis for the origin of aplastic anemia and periodic hematopoiesis","volume":"51","author":"Mackey MC","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1182\/blood.V59.1.27.27","article-title":"Cyclic neutropenia (CN): A clue to the control of granulopoiesis","volume":"59","author":"von Schulthess GK","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198101000-00001"},{"key":"e_1_2_1_7_2","first-page":"435","article-title":"Cyclic hematopoiesis: Human cyclic neutropenia","volume":"11","author":"Lange RD","year":"1983","journal-title":"Exp Hematol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1182\/blood.V60.6.1263.1263","article-title":"Human cyclic neutropenia transferred by allogenic bone marrow grafting","volume":"60","author":"Krance RA","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-35-6-1365"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V8.10.923.923","article-title":"Cyclic neutropenia with giant follicular lymphoblastoma and lymphosarcoma, report of a case with splenectomy","volume":"8","author":"Natelson RP","year":"1953","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1182\/blood.V61.5.1024.1024","article-title":"Lithium is an effective therapy for human cyclic hematopoiesis","volume":"61","author":"Hammond WP","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197802092980602"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830130110"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1182\/blood.V62.2.320.320","article-title":"Cyclic neutropenia: Amplification of granulocyte oscillations by lithium and long\u2010term suppression of cycling by plasmapheresis","volume":"62","author":"von Schulthess GK","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_15_2","first-page":"1131","article-title":"A family of cyclic neutropenia","volume":"16","author":"Nakamura K","year":"1975","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80207-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207092"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81340-1"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood.V23.4.526.526","article-title":"Reticulin fibrosis and bone infarction in acute leukemia. 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