{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:29Z","timestamp":1761708029254},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7376,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased platelet aggregation and high plasma concentration of \u03b2\u2010thromboglobulin were observed in hemizygotes and heterozygotes of Fabry's disease. Carbamazepine and phenytoin administered for the treatment of pains in these patients showed no significant effect on platelet aggregation. No activation of platelets was observed after the addition of ceramide trihexoside, the storage lipid of this disease. Mitral valve prolapse was found in eight of 12 patients. Although the pathogenesis of platelet activation and mitral valve prolapse are not known, the platelet activation could be an early indicator and an accelerating factor of thromboembolic vascular change in this disease.<\/jats:p>","DOI":"10.1002\/ajh.2830220110","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:24:38Z","timestamp":1172053478000},"page":"63-67","source":"Crossref","is-referenced-by-count":23,"title":["Activation of platelet function in Fabry's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Takashi","family":"Igarashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sakuraba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-6-733"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/194927b0"},{"key":"e_1_2_1_4_2","first-page":"149","volume-title":"Technical Hematology","author":"Brecher G","year":"1963"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)90810-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol regent","volume":"193","author":"Lowry OH","year":"1951","journal-title":"J Biol Chem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0022-2275(20)42667-7","article-title":"Concentration of glycosyl ceramide in plasma and red cells in Fabry's disease, a glycolipid lipidosis","volume":"10","author":"Vance DE","year":"1969","journal-title":"J Lipid Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90287-8"},{"key":"e_1_2_1_9_2","first-page":"906","volume-title":"The Metabolic Basis of Inherited Disease","author":"Desnick RJ","year":"1983"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/apm.1966.68.3.332","article-title":"A biochemical investigation of angiokeratoma corporis diffusum","volume":"68","author":"Christensen LHO","year":"1966","journal-title":"Acta Pathol Microbiol Scand"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500110045008"},{"key":"e_1_2_1_12_2","first-page":"323","article-title":"Stroke: A complication of mitral\u2010leaflet prolapse","volume":"2","author":"Kostuk WJ","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.3.384"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830190104"},{"key":"e_1_2_1_15_2","unstructured":"SakurabaH YanagawaY IgarashiT SuzukiY SuzukiT WatanabeK IekiK ShimodaK YamanakaT: Cardiovascular manifestations in Fabry's disease.Clin Genetics(in press)."}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830220110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830220110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T19:32:45Z","timestamp":1698003165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830220110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1002\/ajh.2830220110"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830220110","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}