{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:44:06Z","timestamp":1761155046989},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7376,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary small intestinal lymphoma (PSIL) represents a heterogenous group of disorders with variable clinical and pathologic features and a characteristic age, socioeconomic, and geographic distribution. In developed countries, PSIL usually occurs as a localized ileal tumor, shows a bimodal age distribution, and most frequently presents with abdominal pain and obstructive symptoms. Histologicaily, most of these tumors are diffuse histiocytic, lymphocytic, or undifferentiated lymphomas. Other variants of PSIL, collectively referred to as immunoproliferative small intestinal disease, occur most often among young patients of poor socioeconomic status in Third World countries, mostly in the Middle East and Mediterranean area. They are characterized by involvement of long loops of the upper small intestine and commonly present with abdominal pain, diarrhea, malabsorption, and clubbing of the fingers. A subgroup of these patients shows a serological abnormality with the appearance of part of the alpha heavy chain of IgA in the serum. Histologically, the lesion appears as a dense diffuse lymphoplasmacytic infiltrate of the mucosa of the upper jejenum or duodenum. A form of malignant lymphoma of true histiocytic origin complicates long\u2010standing celiac disease. The contrasting clinical, epidemiological, histopathological, and immunological features of these variants of PSIL raise interesting questions about the pathogenesis of small bowel lymphoma.<\/jats:p>","DOI":"10.1002\/ajh.2830220114","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:24:38Z","timestamp":1172053478000},"page":"89-105","source":"Crossref","is-referenced-by-count":30,"title":["Primary lymphomas of the small intestine: East\u2010west contrast"],"prefix":"10.1002","volume":"22","author":[{"given":"Hamid","family":"Al\u2010Mondhiry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196603000-00002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3860.1396"},{"issue":"2","key":"e_1_2_1_4_2","first-page":"350","article-title":"Alpha chain disease: Clinicopathological features and relationship to so\u2010called Mediterranean lymphoma","volume":"31","author":"Doe WF","year":"1975","journal-title":"Br J Cancer"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076161"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071844"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197712)40:6<2941::AID-CNCR2820400628>3.0.CO;2-L"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.7.627"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1979.tb02986.x"},{"key":"e_1_2_1_10_2","first-page":"111","article-title":"Primary small intestinal lymphomas and \u03b1\u2010heavychain disease: A study of 43 cases from a pathology department in Israel","volume":"15","author":"Selzer G","year":"1979","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197804)41:4<1340::AID-CNCR2820410419>3.0.CO;2-0"},{"key":"e_1_2_1_12_2","first-page":"271","article-title":"Natural history of alpha\u2010chain disease and the socalled Mediterranean lymphoma. Recent results","volume":"64","author":"Rambaud JC","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831101)52:9<1666::AID-CNCR2820520920>3.0.CO;2-P"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1979.tb00302.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198306093082309"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0300-5089(21)00604-0","article-title":"Small intestinal lymphomas and alpha\u2010chain disease","volume":"12","author":"Rambaud JC","year":"1983","journal-title":"Clin Gastroent"},{"key":"e_1_2_1_17_2","first-page":"1809","volume-title":"Cancer Medicine","author":"Mortel CG","year":"1982"},{"key":"e_1_2_1_18_2","first-page":"465","volume-title":"Textbook of Gastroenterology","author":"Bouchier IAD","year":"1984"},{"key":"e_1_2_1_19_2","first-page":"635","volume-title":"Cancer: Principles and Practice of Oncology","author":"Sindelar WF","year":"1982"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197605)37:5<2224::AID-CNCR2820370511>3.0.CO;2-W"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1975.01360080084016"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)33023-1"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4015-7_8"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90421-7"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1755::AID-CNCR2820400452>3.0.CO;2-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820201)49:3<445::AID-CNCR2820490309>3.0.CO;2-1"},{"key":"e_1_2_1_27_2","unstructured":"Al\u2010BahraniZR Al\u2010MondhiryH Al\u2010SaleemT ZainS:Primary lymphomas of the small intestine in Iraqi children. Oncology in press."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1148\/92.6.1355"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<693::AID-CNCR2820420241>3.0.CO;2-J"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820315)49:6<1258::AID-CNCR2820490630>3.0.CO;2-4"},{"key":"e_1_2_1_31_2","volume-title":"Atlas of Tumour Pathology, Section III, Fascicule 8","author":"Rappaport H","year":"1966"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:8 <1488::AID-CNCR2820340822>3.0.CO;2-C"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-96605-7"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1977.tb01644.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820601)49:11<2321::AID-CNCR2820491120>3.0.CO;2-C"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820601)49:11<2376::AID-CNCR2820491126>3.0.CO;2-B"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198311243092102"},{"key":"e_1_2_1_39_2","first-page":"1860","article-title":"Report of the committee on Hodgkin's disease staging classification","volume":"31","author":"Carbone PP","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800701)46:1<215::AID-CNCR2820460136>3.0.CO;2-6"},{"key":"e_1_2_1_41_2","first-page":"1115","volume-title":"Gastrointestinal Disease. Pathophysiology, Diagnosis, Management","author":"Trier JS","year":"1978"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198109243051305"},{"key":"e_1_2_1_43_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood.V63.5.1102.1102","article-title":"An effective therapy for both undifferentiated (including Burkitt's) lymphomas and lymphoblastic lymphomas in children and young adults","volume":"63","author":"Magarth IT","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.3.3.232"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90071-X"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.17.8.612"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90004-1"},{"key":"e_1_2_1_48_2","first-page":"193","volume-title":"Recent Advances in Gastrointestinal Pathology","author":"Isaacson P","year":"1980"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.5.510"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314465"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91754-3"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.5.1544"},{"key":"e_1_2_1_53_2","first-page":"615","article-title":"Alpha chain disease and related small intestinal lymphoma: A memorandum","volume":"54","year":"1976","journal-title":"Bull WHO"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197612)38:6<2511::AID-CNCR2820380641>3.0.CO;2-U"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<870::AID-CNCR2820550428>3.0.CO;2-8"},{"key":"e_1_2_1_56_2","first-page":"390","article-title":"Primary malignant lymphoma of the small intestine in Israel: changing incidence with time","volume":"15","author":"Selzer G","year":"1979","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197206)29:6<1502::AID-CNCR2820290614>3.0.CO;2-O"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4015-7_14"},{"key":"e_1_2_1_59_2","first-page":"440","article-title":"The mutual clonal origin of the lymphoplasmacytic and lymphoma cell in alpha\u2010heavy chain disease","volume":"27","author":"Ramot B","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92705-8"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.20.3.226"},{"key":"e_1_2_1_62_2","first-page":"386","article-title":"Primary intestinal lymphoma in South Africa","volume":"15","author":"Novis BH","year":"1979","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.2.136"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)93057-1"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197706)39:6<2579::AID-CNCR2820390641>3.0.CO;2-J"},{"key":"e_1_2_1_66_2","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1093\/ajcn\/32.10.1994","article-title":"Lactose intolerance in the Lebanese population and in \u201cMediterranean lymphoma","volume":"32","author":"Nasrallah SM","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_67_2","first-page":"491","article-title":"Immunoproliferative small intestinal disease with duodenojejunal lymphoma: Radiologic changes","volume":"135","author":"Vessal K","year":"1980","journal-title":"Am J Radiol"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1148\/126.2.379"},{"key":"e_1_2_1_69_2","first-page":"1","article-title":"Observations on the etiology of primary intestinal lymphoma","volume":"4","author":"Bakir F","year":"1982","journal-title":"J Infect Dis"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106204"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1978.7"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92930-7"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830220114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830220114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T19:34:07Z","timestamp":1698003247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830220114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1002\/ajh.2830220114"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830220114","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}