{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:31:49Z","timestamp":1697981509857},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7345,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The secretion of interferon (IFN)\u2010\u03b3 by T lymphocytes is mediated by the synthesis of interleukin 2 (IL\u20102) and the availability of IL\u20102 receptors. Since some Burkitt's lymphoma lines express Tac antigen and can be triggered to secrete IL\u20102 following activation with the new tumor promoter teleocidin, we addressed the question of whether the induction of IL\u20102 by B lymphocytes is accompanied by the induction of IFN\u2010\u03b3. IFN\u2010\u03b3 has not been detected in any of the 25 cell lines studied, and following stimulation with teleocidin, we triggered the synthesis of IFN\u2010\u03b3 in JLP(C), a pre\u2010Burkitt's cell line.<\/jats:p><jats:p>The mechanism of IFN\u2010\u03b3 secretion by B lymphocytes is not clear. Our findings demonstrate that the synthesis of IL\u20102 by B cells is not accompanied by IFN\u2010\u03b3 and suggest that the synthesis of IFN\u2010\u03b3 is not mediated by IL\u20102 or IL\u20101 or B\u2010cell growth factor. Neutralization studies have shown that IFN\u2010\u03b3 secretion is not accompanied by the induction of IFN\u2010\u03b1 or IFN\u2010\u03b2.<\/jats:p><jats:p>Our data imply that B cells can be triggered to secrete IFN\u2010\u03b3 under certain circumstances. Whether similar function occurs in vivo is not known.<\/jats:p>","DOI":"10.1002\/ajh.2830220207","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:49:23Z","timestamp":1172054963000},"page":"169-177","source":"Crossref","is-referenced-by-count":11,"title":["Burkitt's cells can be triggered by teleocidin to secrete interferon\u2010\u03b3"],"prefix":"10.1002","volume":"22","author":[{"given":"David","family":"Benjamin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan P.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard S.","family":"Bazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"305","volume-title":"Interferons","author":"Georgiades JA","year":"1984"},{"key":"e_1_2_1_3_2","first-page":"248","article-title":"Virus interference. 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