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Following infusion of DDAVP (0.3\u20130.4 \u03bcg\/kg), prolonged bleeding time was normalized; plasma ristocetin cofactor activity, von Willebrand factor antigen, and factor VIII activity were remarkably increased; and high\u2010molecular\u2010weight forms of von Willebrand factor were demonstrated by crossed immunoelectrophoresis in both patients. Excellent hemostasis was achieved following adminstration of DDAVP in one patient when it was used for the treatment of gum bleeding and for the prophylaxis of bleeding during and after dental extractions. These observations suggest that DDAVP is an effective alternative to blood products for at least some patients with acquired von Willebrand syndrome in addition to patients with inherited von Willebrand disease, hemophilia A, and uremia.<\/jats:p>","DOI":"10.1002\/ajh.2830220412","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:46:53Z","timestamp":1172054813000},"page":"421-429","source":"Crossref","is-referenced-by-count":31,"title":["DDAVP in acquired von Willebrand syndrome associated with multiple myeloma"],"prefix":"10.1002","volume":"22","author":[{"given":"Hoyu","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reizo","family":"Nagayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Hanano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Mito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"662","article-title":"Studies on the prolonged bleeding time in von Willebrand's disease","volume":"88","author":"Mannucci PM","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.132.133"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02789.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1182\/blood.V59.6.1272.1272","article-title":"Multimeric composition of factor VIII\/von Willebrand factor following administration of DDAVP: Implications for pathophysiology and therapy of von Willebrand's disease subtypes","volume":"59","author":"Ruggeri ZM","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91197-7"},{"key":"e_1_2_1_7_2","first-page":"359","volume-title":"Proceedings of the Third International Symposium on Hemophilia Treatment","author":"Takahashi H","year":"1982"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80526-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-1-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301063080102"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830050411"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1182\/blood.V54.3.600.600","article-title":"Selective absence of large forms of factor VIII\/von Willebrand factor in acquired von Willebrand's syndrome. 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