{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:56Z","timestamp":1760188856132},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pure red cell aplasia (PRCA) results from the failure of erythrocyte differentiation and may respond to immunosuppressive therapies. We have treated nine patients with PRCA refractory to steroids and\/or cyclophosphamide with anti\u2010thymocyte globulin (ATG). Six patients had normal numbers of erythroid bursts (from erythroid burstforming units) or erythroid colonies (from erythroid colony\u2010forming units) detectable in vitro, and all responded to therapy with ATG. In vitro studies suggested T\u2010cell inhibition of erythropoiesis in four of these six patients and humorally mediated erythroid suppression in one. In three individuals, virtually no erythroid progenitors were detected in marrow culture. None of these patients responded to ATG. Myelo\u2010fibrosis, 5q\u2010 chromosomal abnormality, or the subsequent development of thrombo\u2010cytopenia in these individuals suggested that PRCA resulted from an intrinsic stem cell disorder. Our studies demonstrate that ATG is effective therapy for PRCA, and it may be especially useful in children or other patients in whom alkylating agents are not appropriate. We also confirm that erythroid growth in marrow culture predicts those patients who will respond to ATG or other immunosuppressive therapies.<\/jats:p>","DOI":"10.1002\/ajh.2830230408","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:38:51Z","timestamp":1172054331000},"page":"363-371","source":"Crossref","is-referenced-by-count":31,"title":["Pure red cell aplasia: Response to therapy with anti\u2010thymocyte globulin"],"prefix":"10.1002","volume":"23","author":[{"given":"Janis L.","family":"Abkowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry S.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall E.","family":"Kadin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Adamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1182\/blood.V56.3.421.421","article-title":"Studies on pure red cell aplasia. 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