{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:50Z","timestamp":1760188850574},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two patients from two separate families were diagnosed as having type IIB von Willebrand disease, because they had lifelong bleeding tendencies, prolonged bleeding times, no large von Willebrand factor multimers, and low levels of ristocetin cofactor in plasma with heightened ristocetin\u2010induced platelet aggregation. There was no history of bleeding, and no laboratory abnormalities were found in the parents and sibship of either propositi, in contrast with the autosomal dominant pattern of inheritance usually observed in type IIB von Willebrand disease. Abnormalities of ristocetin\u2010induced von Willebrand factor\u2010platelet interactions were less severe than in a patient from a previously reported family with type IIB von Willebrand disease studied in parallel. The peculiar features of these cases provide additional evidence of the existence of heterogeneity within this variant.<\/jats:p>","DOI":"10.1002\/ajh.2830230410","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:38:51Z","timestamp":1172054331000},"page":"381-390","source":"Crossref","is-referenced-by-count":13,"title":["Heterogeneity in type IIB von Willebrand disease: Two unrelated cases with no family history and mild abnormalities of ristocetin\u2010induced interaction between von willebrand factor and platelets"],"prefix":"10.1002","volume":"23","author":[{"given":"A. B.","family":"Federici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lattuada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005083021902"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109795"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1182\/blood.V59.6.1272.1272","article-title":"Multimeric composition of factor VIII\/von Willebrand factor following administration of DDAVP: Implications for pathophysiology and therapy of von Willebrand's disease subtypes","volume":"59","author":"Ruggeri ZM","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(77)90204-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90231-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310063091402"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07333.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112132"},{"key":"e_1_2_1_10_2","first-page":"1126","article-title":"Type II B von Willebrand's discase presenting as a lifelong bleeding diathesis associated with chronic thrombocytopenia and spontaneous platelet aggregation","volume":"54","author":"Giles AR","year":"1985","journal-title":"Thromb Haemostas"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1182\/blood.V66.2.282.282","article-title":"Type II B Tampa: a variant of von Willebrand disease with chronic thrombocytopenia, circulating platelet aggregates, and spontaneous platelet aggregation","volume":"66","author":"Saba HI","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03533.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202113060603"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1182\/blood.V60.3.790.790","article-title":"Platelet\u2010type von Willebrand's disease: Characterization of a new bleeding disorder","volume":"60","author":"Miller JL","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1182\/blood.V64.6.1254.1254","article-title":"Further characterization of platelet\u2010type von Willebrand's disease in Japan","volume":"64","author":"Takahashi M","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111628"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1182\/blood.V64.3.614.614","article-title":"Studies of the pathophysiology of acquired von Willebrand's disease in seven patients with lympho\u2010proliferative disorders or benign monoclonal gammopathy","volume":"64","author":"Mannucci PM","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.6.1140.1140"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood.V66.4.796.796","article-title":"Heterogeneity of type I von Willebrand disease. 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