{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:32:28Z","timestamp":1790836348932,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":7131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Red cell morphology was studied after the induction of echinocytic transformation by metabolic depletion, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    loading, and salicylate and stomatocytic transformation with chlorpromazine. The results indicate that the red cell has an energy\u2010dependent shape control mechanism that allows it to counteract shape\u2010changing stimuli such as metabolic depletion. Albumin was found to induce stomatocytic transformation, whereas \u03b3\u2010globulins induced echinocytic transformation. Loading of the red cell with calcium resulted in polymorphous membrane damages such as submembranous, \u201cblister\u2010like\u201d lesions, and membrane disintegration; the red cell age had no influence on this process. Conversely, the stomatocyte\u2010echinocyte transformation induced by chlorpromazine and salicylate was shifted towards echinocytes in density\u2010separated old red cells. Sphero\u2010stomatocytes were capable of echinocytic transformation with spicule formation within the red cell vacuoles, whereas sphero\u2010echinocytes were unable to undergo stomatocytic transformation without hemolysis. These observations may help to unravel the complexity of echinocyte\u2010stomatocyte transformation of red blood cells.\n                  <\/jats:p>","DOI":"10.1002\/ajh.2830240102","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:38:30Z","timestamp":1172036310000},"page":"1-14","source":"Crossref","is-referenced-by-count":63,"title":["Echinocyte\u2010stomatocyte transformation and shape control of human red blood cells: Morphological aspects"],"prefix":"10.1002","volume":"24","author":[{"given":"Walter H.","family":"Reinhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/310368a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(68)90078-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.11.4457"},{"key":"e_1_2_1_5_2","first-page":"175","article-title":"Membrane skeletal dynamics: Role in modulation of red cell deformability, mobility of transmembrane proteins, and shape","volume":"20","author":"Sheetz MP","year":"1983","journal-title":"Semin Hematol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1967.tb08728.x"},{"key":"e_1_2_1_7_2","first-page":"500","volume-title":"Metabolites. 3. 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