{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:26:50Z","timestamp":1765826810799},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess the role of platelets in thrombohemorrhagic complications of acute respiratory failure (ARF), we studied platelet function in 13 ARF patients admitted for intensive care, in six acutely ill intensive care patients without evidence of acute lung injury (non\u2010ARF), and in 10 normal subjects. Platelet counts in ARF and non\u2010ARF patients were similar to the normal range. The bleeding time of the ARF patients (8.5 \u00b1 0.9 min) was significantly longer (p &lt; 0.01) than the normal (4.8 \u00b1 0.2 min) but similar to non\u2010ARF patients (5.4 \u00b1 0.8 min). The bleeding time prolongations in ARF patients were unrelated to platelet concentration. Platelet aggregation induced by ADP and thrombin was normal in both ARF and non\u2010ARF patient groups. The epinephrine response was impaired in one non\u2010ARF patient and in three ARF patients; collagen\u2010induced aggregation was absent in two ARF patients, with a prolonged bleeding time. Levels of VIII:C and vWF in both groups of patients were similar to the normal level, but VIIIR:Ag levels in ARF patients (407 \u00b1 45% of normal) were higher (p &lt; 0.01) than in both non\u2010ARF patients (210% \u00b1 10%) and normal subjects (106% \u00b1 4). The electrophoretic mobility of VIIIR:Ag was abnormal in ARF patients. The prolonged bleeding time in ARF patients appears to result from the qualitative and quantitative VIIIR:Ag defect. \u03b2\u2010Thromboglobulin levels were greater (p &lt; 0.01) in ARF patients (87.6 \u00b1 6.9 ng\/ml; p &lt; 0.001) than in non\u2010ARF patients (46.2 \u00b1 3.1 ng\/ml) or in normal subjects (25.3 \u00b1 2.5 ng\/ml p &lt; 0.0001). However, platelet factor 4 plasma levels in ARF patients (18 \u00b1 1.6 ng\/ml) did not differ from those in non\u2010ARF patients (15.0 \u00b1 3.0 ng\/ml), but both were significantly different from normal (6.1 \u00b1 0.8 ng\/ml). Plasma thromboxane B<jats:sub>2<\/jats:sub> (T \u00d7 B<jats:sub>2<\/jats:sub>) levels were not different from normal values in either ARF or non\u2010ARF patients, but 6\u2010keto\u2010PFG<jats:sub>1\u03b1<\/jats:sub> levels were significantly reduced (p &lt; 0.01) in ARF patients (215 \u00b1 43 pg\/ml) compared to normal values (381 \u00b1 34 pg\/ml). Non\u2010ARF patients had 6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub> levels (285 \u00b1 111 pg\/ml) midway between the normal values and those of ARF patients. Our results suggest that in vivo platelet activation occurs in ARF. ARF patients have quantitative and qualitative platelet defects that may contribute to thrombotic and hemorrhagic complications.<\/jats:p>","DOI":"10.1002\/ajh.2830250404","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:07:03Z","timestamp":1172056023000},"page":"377-388","source":"Crossref","is-referenced-by-count":14,"title":["Platelet function in acute respiratory failure"],"prefix":"10.1002","volume":"25","author":[{"given":"Angelina C.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Demarinis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie G.","family":"Beitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren M.","family":"Zapol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"246","article-title":"Pulmonary microembolism after soft tissue injury in primates","volume":"70","author":"Berman IR","year":"1971","journal-title":"Surgery"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(79)90002-1"},{"key":"e_1_2_1_4_2","first-page":"199","article-title":"Adult respiratory distress syndrome: Early predictors of mortality. 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