{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:40Z","timestamp":1760188840504},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6858,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Platelet function and factor VIII complex were evaluated in ten patients with polycythemia rubra vera. Seven patients showed abnormal epinephrine\u2010induced aggregation. The intracellular concentrations of adenosine diphosphate (ADP) were below normal, and the ratio of adenosine triphosphate (ATP)\/ADP was greater than normal. In four of eight cases, there was a decrease in ristocetin cofactor activity and a reduction in the slowly migrating forms of vWF:Ag on crossed immunoelectrophoresis. Defect of large multimers of vWF:Ag was also observed. The ratio of vWF:Ag to ristocetin cofactor was elevated in these patients. Plasma from the patients had no effect on normal plasma except in one case, in which isolated IgG appeared to cause inactivation of ristocetin cofactor. Treatment with 1\u2010deamino\u20108\u2010arginine vasopressin caused correction of the vWF abnormalities with rapid return of ristocetin cofactor to baseline in some patients. The present study shows that the alterations of multimeric structure of vWF occur in more than 50% of patients with polycythemia rubra vera and are in some part due to the inhibitor specific for vWF.<\/jats:p>","DOI":"10.1002\/ajh.2830260204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:03:33Z","timestamp":1172055813000},"page":"135-146","source":"Crossref","is-referenced-by-count":38,"title":["Acquired von willebrand disease in patients with polycythemia rubra vera"],"prefix":"10.1002","volume":"26","author":[{"given":"Hiroshi","family":"Mohri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb05836.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(81)90100-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1055\/s-0038-1646838","article-title":"Abnormalities of platelet adenine nucleotides in patients with myeloproliferative disorders","volume":"41","author":"Nishimura J","year":"1979","journal-title":"Throm Haemost"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1055\/s-0038-1666917","article-title":"Detection of acquired platelet storage pool disease in three patients with a myeloproliferative disorder","volume":"42","author":"Rendu F","year":"1979","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1182\/blood.V52.3.618.618","article-title":"Platelet resistance to prostaglandin D2 in patients with myeloproliferative disorders","volume":"52","author":"Cooper B","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197809072991002"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.V31.6.806.806","article-title":"Acquired von Willebrand's syndrome in systemic lupus erythematosis","volume":"31","author":"Simone JV","year":"1968","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1971.tb03429.x"},{"key":"e_1_2_1_10_2","first-page":"1579","article-title":"Platelet function in chronic lymphocytic leukemia","volume":"48","author":"Mohri H","year":"1985","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1976.tb01127.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1182\/blood.V48.3.393.393","article-title":"Antibody\u2010induced von Willebrand's disease: A newly defined inhibitor syndrome","volume":"48","author":"Handin RI","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.5.981.981"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02830.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1182\/blood.V54.3.600.600","article-title":"Selective absence of large forms of factor VIII\/von Willebrand factor in acquired von Willebrand's syndrome. Response to transfusion","volume":"54","author":"Meyer D","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07497.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02700.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220408"},{"key":"e_1_2_1_19_2","first-page":"1418","article-title":"Platelet dysfunction in patients with essential thrombocythemia\u2014Acquired von Willebrand disease","volume":"49","author":"Mohri H","year":"1986","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_20_2","first-page":"653","article-title":"Clinical trial of Simplate bleeding time","volume":"30","author":"Mohri H","year":"1986","journal-title":"Med Technol"},{"key":"e_1_2_1_21_2","first-page":"724","article-title":"Measurement of platelet adhesiveness: A simple in vitro technique demonstrating an abnormality in von Willebrand's disease","volume":"62","author":"Salzman EW","year":"1963","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/194927b0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(72)90323-5"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90246-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(65)90278-2"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661533"},{"key":"e_1_2_1_27_2","first-page":"756","article-title":"A rapid quantitative macroscopic assay for von Willebrand factor (WF)","volume":"35","author":"Reisner HM","year":"1976","journal-title":"Fed Proc"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1970.tb01648.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood.V48.4.511.511","article-title":"Acquired storage pool disease in platelets during disseminated intravascular coagulation","volume":"48","author":"Pareti FI","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90819-5"},{"key":"e_1_2_1_31_2","first-page":"198","article-title":"Detection of activated platelets and the evaluation of antiplatelet drugs","volume":"42","author":"Tsukada T","year":"1979","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_32_2","first-page":"203","article-title":"Von Willebrand's disease","volume":"6","author":"Zimmerman TS","year":"1982","journal-title":"Prog Hemost Thromb"},{"key":"e_1_2_1_33_2","first-page":"54","article-title":"Multiple molecular forms of factor VIII antigen in normal individuals and von Willebrand's disease patients","volume":"38","author":"Zimmerman TS","year":"1977","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb02091.x"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650099"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb08484.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/85.1.115"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/87.5.663"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03575.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1182\/blood.V58.4.665.665","article-title":"Acquired von Willebrand's disease in association with Wilm's tumor: Regression followig treatment","volume":"58","author":"Scott JP","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_41_2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1182\/blood.V59.6.1272.1272","article-title":"Multimeric composition of factor VIII\/von Willebrand factor following administration of DDAVP. Implication for pathophysiology and therapy of von Willebrand disease subtypes","volume":"59","author":"Ruggeri ZM","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1182\/blood.V64.3.614.614","article-title":"Studies of the pathophysiology of acquired von Willebrand's disease in seven patients with lymphoproliferative disorders or benign monoclonal gammopathies","volume":"64","author":"Mannucci PM","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220412"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830210310"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830260204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830260204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:54:27Z","timestamp":1697867667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830260204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1002\/ajh.2830260204"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830260204","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}