{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:33:48Z","timestamp":1761762828712},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":6827,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Protein 4.1, an important component of the red cell membrane skeleton, was quantitated relative to protein 3 after sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS\u2010PAGE) of membranes isolated from red cells of members of 14 kindreds with hereditary elliptocytosis (HE) who reside in South Africa. A partial deficiency of protein 4.1 (mean 30% reduction) was inherited in autosomal dominant fashion in five white kindreds giving a frequency of 0.36 of HE families studied. Immunoblots of membrane proteins separated by SDS\u2010PAGE and probed with a monoclonal antibody to protein 4.1 did not reveal any proteolytic fragments in the 4.1\u2010deficient subjects that could account for the reduction of this protein. These studies draw attention to the relatively high frequency of this condition as a cause of HE in white subjects in this country.<\/jats:p>","DOI":"10.1002\/ajh.2830260308","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:02:20Z","timestamp":1172055740000},"page":"263-272","source":"Crossref","is-referenced-by-count":6,"title":["Partial deficiency of protein 4.1 in hereditary elliptocytosis"],"prefix":"10.1002","volume":"26","author":[{"given":"S.","family":"Lambert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"225","article-title":"The influence of membrane skeleton on red cell deformability, membrane material properties and shape","volume":"20","author":"Mohandas N","year":"1983","journal-title":"Semin Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/307655a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1016\/S0021-9258(19)83676-1","article-title":"Interactions between protein 4.1 and band 3. 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